CT引导放射性^(125)I粒子植入治疗纵隔转移瘤11例  

CT-guided radioactive ^(125)I seed implantation for the treatment of mediastinal metastases: initial results in 11 patients

作　　者：朱先海[1] 王伟昱[1] 秦汉林[1] 施长杲[1] 许军[1] 谢韬[1] 周磊[1] ZHU Xianhai WANG We@u QING Hanlin SHI Changgao XU Jun XIA Tao ZHOU Lei.(Department of lnterventional Oncology, Anhui Provincial Tumor Hospital, West Branch of Anhui Provincial Hospital, Hefei, Anhui Province 230061, China)

机构地区：[1]安徽省肿瘤医院(安徽省立医院)西区肿瘤介入科,合肥230061

出　　处：《介入放射学杂志》2017年第7期632-635,共4页Journal of Interventional Radiology

摘　　要：目的探讨CT引导放射性125I植入治疗纵隔淋巴结转移瘤的方法、安全性和临床疗效。方法对11例纵隔淋巴结转移瘤患者行CT引导下放射性125I粒子植入治疗,术前采用近距离治疗计划系统(TPS)制定计划,选择粒子活度:(1.11~2.96)×107Bq(0.3~0.8 m Ci),术后观察并发症发生情况,术后1、3、6、12个月评价肿瘤局部控制率、疼痛缓解有效率。结果术后出现气胸3例,气管瘘1例,肺部感染1例。随访1、3、6、12个月,患者局部控制率为81.8%、90.9%、72.7%、72.7%;疼痛缓解有效率,1周100%、1个月90.9%、3个月90.9%、6个月81.8%、12个月72.7%。结论 CT引导放射性125I粒子植入治疗纵隔转移瘤创伤小、并发症少、局部病灶控制率确切,是一种较为安全的治疗方法。Objective To discuss the technical method, safety and clinical efficacy of CT-guided ^125I radioactive seed implantation for the treatment of mediastinal lymph node metastases. Methods CT- guided ^125I radioactive seed implantation was carried out in 11 patients with mediastinal lymph node metastases. Before ^125I seed implantation, the interstitial brachytherapy treatment planning system （TPS） was employed to formulate a treatment plan. The particles with radioactivity of （1.11-2.96） × 10^7Bq （0.3-0.8 mCi） were used for the implantation. Postoperative complications were recorded. The local lesion control rate and the effective rate of pain relief were evaluated at one, 3, 6 and 12 months after ^125I seed implantation. Results After ^125I seed implantation, pneumothorax occurred in 3 patients, tracheal fistula in one patient, and pulmonary infection in one patient. The local lesion control rates at one, 3, 6 and 12 months were 81.8%, 90.9%, 72.7% and 72.7% respectively; the effective rate of pain relief at one week, one, 3, 6 and 12 months were 100%, 90.9%, 90.9%, 81.8% and 72.7% respectively. Conclusion For the treatment of mediastinal lymph node metastases, CT-guided radioactive ^125I seed implantation is less-invasive with less complications, and it carries reliable local lesion control rate. Therefore, this technique is a safe therapeutic means.

关 键 词：纵隔淋巴结转移瘤 ^125I粒子植入 近距离放射治疗 

分 类 号：R730.44[医药卫生—肿瘤] R734.5[医药卫生—临床医学]