血清同型半胱氨酸在双相障碍、精神分裂症和抑郁症中的表达  

Expression of serum homocysteine in bipolar disorder,schizophrenia and depression

作　　者：谢筱颖[1] 黄炜[1] 陈家强[1] 张铭[1] 

机构地区：[1]佛山市第三人民医院,广东佛山528000

出　　处：《四川精神卫生》2017年第3期282-284,共3页Sichuan Mental Health

摘　　要：目的探讨血清同型半胱氨酸(Hcy)在双相障碍、精神分裂症和抑郁症患者中的水平。方法以2016年5月-10月在佛山市第三人民医院住院的符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)诊断标准的双相障碍(168例)、精神分裂症(231例)和抑郁症患者(100例)为患者组,以同期佛山市第三人民医院的健康体检者112名作为对照组,采用循环酶法检测所有研究对象的血清Hcy水平。结果各组血清Hcy水平组内比较,男性均高于女性,差异均有统计学意义(P均<0.05);双相障碍组和精神分裂症组血清Hcy水平均高于对照组和抑郁症组,差异均有统计学意义(P均<0.05),但双相障碍组与精神分裂症组,对照组与抑郁症组间的血清Hcy水平差异均无统计学意义(P均>0.05)。结论双相障碍和精神分裂症患者的血清Hcy水平均呈高表达,抑郁症患者血清Hcy水平未升高,Hcy水平可能存在性别差异。Objective To explore the expression of serum homocysteine （ Hey） in patients with bipolar disorder, schizophrenia and depression. Methods Patients of bipolar disorder （ 168 c a s e s ） ,schizophrenia （ 231 cases） and depression （100 cases） who hospitalized in the Third Peoples Hospital of Foshan from May to October, 2016 were included as patient group. All of the patients accorded with the diagnosis standard of the Chinese Classification and Diagnostic Criteria of Mental Disease, third edition （ CCMD - 3 ） . At the same time, 112 healthy controls from the Third Peoples Hospital of Foshan were included as control group. The serum Hey level was detected with the enzymatic cycling assay in the subjects of two groups. Results The serum Hey level of male was higher than the female in each group （all P 〈0. 05） . The serum Hey levels of bipolar disorder group and schizophrenia group apparently were higher than the depression group and control group （all P 〈 0. 05 ） . The difference of serum Hey level between bipolar disorder group and schizophrenia group was not statistically significant, the difference of serum Hey level between depression group and control group was not statistically significant （all P 〉0.05）. Conclusion The serum Hey level in patients with bipolar disorder and schizophrenia show high expression, while it does not rise in the depression patients. The serum Hey level may be difference between different gender.

关 键 词：同型半胱氨酸 双相障碍 精神分裂症 抑郁症 

分 类 号：R749[医药卫生—神经病学与精神病学]