深圳龙华新区人民医院母乳喂养儿维生素D水平及与相关指标关系  

Relationship between vitamin D level and related indicators in breastfeeding infants in People＇s Hospital of Longhua New District in Shenzhen City

作　　者：吴娟 胡一冰 徐妮 Wu Juan Hu Yibing Xu Ni(Department of Pediatrics, People＇s Hospital of Longhua New District, Shenzhen , Guangdong 518109, China)

机构地区：[1]深圳市龙华新区人民医院住院部儿科,518109

出　　处：《中华临床营养杂志》2017年第3期167-170,共4页Chinese Journal of Clinical Nutrition

摘　　要：目的 探讨深圳龙华新区人民医院婴儿采用母乳结合补充维生素D喂养0～8个月的维生素D水平变化及其与骨碱性磷酸酶（BAP）、甲状旁腺素（PTH）之间的关系.方法 选择2016年4至6月在深圳市龙华新区人民医院妇产科分娩生产的67例新生儿作为研究对象,采用母乳喂养并在出生15 d后开始补充维生素D 400 U/d,在0、4、8月龄分别取静脉血检测血清25-（OH）D3及BAP、PTH水平,采用Pearson相关分析法分析血清25-（OH）D3与BAP、PTH的相关性.结果 与刚出生时比较,婴儿在4月龄、8月龄的血清25-（OH）D3[（78.47±36.41）nmol/L、（75.26±34.73）nmol/L]、BAP[（231.43±78.81）μg/L、（205.97±71.64）μg/L]、PTH[（31.76±11.54）pg/ml、（32.94±13.82）pg/ml]水平均明显提高,差异均有统计学意义（t4月=7.823、12.568、11.852,t8月=7.364、9.473、11.947,P均=0.000）.婴儿刚出生、4月龄、8月龄时的血清25-（OH）D3与BAP均呈负相关（r=-0.372、-0.463、-0.309,P=0.008、0.016、0.021）;婴儿4月龄、8月龄时血清BAP与PTH呈正相关（r=0.487、0.338,P=0.005、0.032）,婴儿4月龄时血清25-（OH）D3与PTH呈负相关（r=-0.297,P=0.041）.结论 深圳城区婴儿在刚出生时容易发生维生素D缺乏,采取母乳结合补充维生素D 400 U/d喂养4个月后,大部分婴儿的维生素D水平能够达到正常.在不同月龄,婴儿25-（OH）D3水平与BAP、PTH之间的相关性存在差异.Objective To investigate the changes of vitamin D level and its relationship with bone alkaline phosphatase（BAP）and parathyroid hormone（PTH）in infants fed with breast milk and vitamin D supplementation for 0-8 months in Peoples Hospital of Longhua New District in Shenzhen city.MethodsTotally 67 newborns in the Department of Obstetrics and Gynecology of Peoples Hospital of Longhua New District were selected.These newborns were breastfed and began to supplement vitamin D 400 U/d in the 15th day after birth.The serum 25-（OH）D3 and BAP and PTH levels were measured in newborns and 4-/8-month-old infants,and the correlations of serum 25-（OH）D3 with BAP and PTH were analyzed by Pearson correlation analysis.ResultsCompared with the newborns,the serum 25-（OH）D3 [（78.47±36.41）nmol/L,（75.26±34.73）nmol/L],BAP[（231.43±78.81）μg/L,（205.97±71.64）μg/L],PTH[（31.76±11.54）pg/ml,and（32.94±13.82）pg/ml] levels of 4-and 8-month-old infants were significantly higher,and the difference were statistically significant（t4 months=7.823,12.568,11.852,t8 months=7.364,9.473,11.947;all P=0.000）.There was a negative correlation between serum 25-（OH）D3 and BAP in newborns and 4-/8-monthold infants（r=-0.372,-0.463,-0.309;P=0.008,0.016,0.021）,the serum BAP was positively correlated with PTH in infants aged 4 months and 8 months（r=0.487,0.338;P=0.005,0.032）,and the serum 25-（OH）D3 was negatively correlated with PTH in infants aged 4 months（r=-0.297,P=0.041）.Conclusions Infants at birth are prone to vitamin D deficiency in Shenzhen City.After 4 months of breastfeeding and vitamin D400U/d supplementation,the vitamin D levels in most infants become normal.25-（OH）D3 is correlated with BAP and PTH in different months.

关 键 词：维生素D 母乳喂养 血清25-(OH)D3 甲状旁腺素 骨碱性磷酸酶 

分 类 号：R153.1[医药卫生—营养与食品卫生学]