2011-2015年我国美沙酮维持治疗人员吸毒过量死亡分析  

STUDY OF DRUG OVERDOSE DEATHS AMONG METHADONE MAINTENANCE TREATMENT CLIENTS IN CHINA,2011-2015

作　　者：王常合[1] 曹晓斌[1] 罗巍[1] 李力[1] 柔克明[1] 吴尊友[1] WANG Changhe CAO Xiaobin LUO Wei LI Li ROU Keming WU Zunyou(The Chinese Center for Disease Control and Prevention Sexually Transmitted Disease of AIDS Prevention and Control Center, Beijing, 102206)

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京102206

出　　处：《中国药物依赖性杂志》2017年第3期205-209,共5页Chinese Journal of Drug Dependence

摘　　要：目的:分析我国参加美沙酮维持治疗吸毒过量死亡人员基本情况和死亡时间分布,为制定降低死亡的措施提供依据。方法:收集2011-2015年全国美沙酮维持治疗门诊报告因吸毒过量死亡的治疗人员基本信息,参加治疗信息,分析死亡人员特点,死亡发生的时间,探讨不同治疗时段死亡的相关因素。结果:2011-2015年间,全国美沙酮维持治疗者累计报告因吸毒过量死亡408例,死亡时平均年龄38.3±7.4岁;第1-4周内死亡人数占总报告死亡人数的28.7%,前8周死亡人数占总报告死亡人数的38.7%;停止服药后4周内死亡人数占总报告死亡人数的54.9%;开始治疗或重新开始治疗4周内死亡人员治疗依从性低于4周以后死亡人员(t=2.63,P=0.009)。结论:参加美沙酮维持治疗人员吸毒过量死亡多发生在治疗(或中断治疗后再次治疗)初始阶段和停止服药后的初期阶段,应针对新参加治疗人员加强干预,对停止治疗人员及时随访,提高治疗依从性。Objective： To analyze the demographic characteristics and the death time distribution of MMT clinics clients who died from drug overdose,and provide evidence for the development of intervention strategy to reduce mortality.Methods： We collected the MMT clients who were reported died from drug overdose from 2011 to 2015,and carried out a descriptive analysis of their demography,drug use history,adoption of MMT and time of death,and tried to explore the factors related to death time of different treatment periods.Results： Between 2011 and 2015,there were 408 cases of death due to drug overdose,and the average age at death was 38. 3 ± 7. 4 years old. The deaths within the first 1-4weeks enrolled in or re-enrolled in MMT accounted for 28. 7% of the total reported deaths,and deaths during the first 8 weeks accounted for 38. 7%. The deaths accounted for 54. 9% of the total reported deaths within 4 weeks after drop-out from MMT. Participants who died within the first 4 weeks enrolled in or re-enrolled in had less treatment compliance than those died after 4 weeks drop-out（ t = 2. 63,P = 0. 009）.Conclusion： MMT clients died from drug overdose often occurred during the initial period of treatment（ or re-enrolled in treatment） and the initial period after drop-out. The specific intervention measures should be aimed at clients who were newly enrolled（ or re-enroll） in and those who often ceased treatment,to improve their treatment compliance.

关 键 词：美沙酮维持治疗 阿片类物质成瘾者 吸毒过量 

分 类 号：R749[医药卫生—神经病学与精神病学]