肠炎康颗粒对溃疡性结肠炎患者血清TNF-α,25-(OH)D,YKL-40水平的影响  

Effect of Changyankang Granules on the TNF-α, 25-(OH)D, YKL-40 Levels of Patients with Ulcerative Colitis

作　　者：杨家群[1] 熊伟[1] 杨琳[1] 肖烨[2] 付芬 

机构地区：[1]重庆医科大学附属第三医院消化科,重庆401120 [2]解放军第324医院消化科,重庆404000 [3]重庆市城南医院消化科,重庆400065

出　　处：《现代生物医学进展》2017年第18期3494-3497,共4页Progress in Modern Biomedicine

基　　金：四川省卫生厅科研基金项目(200001)

摘　　要：目的:探讨肠炎康颗粒治疗溃疡性结肠炎的疗效及其对患者血清肿瘤坏死因子-α(TNF-α)、25-羟维生素D(25-(OH)D)、甲壳质酶蛋白40(YKL-40)水平的影响。方法:将98例溃疡结肠炎患者参照随机数表法分作对照组(n=49)与研究组(n=49),对照组予以常规治疗,研究组基于对照组加用肠炎康颗粒治疗,比较两组的临床疗效,治疗前后血清TNF-α、25-(OH)D、YKL-40,丙二醇(MDA)、超氧化物歧化醇(SOD),血小板计数(PLT)、D-二聚体(D-D),CD3^+、CD4^+、CD8^+、CD4^+/CD8^+的变化情况以及不良反应的发生情况。结果:治疗后,研究组总有效率显著高于对照组,差异有统计学意义(P<0.05),,研究组血清TNF-α、YKL-40、MDA、PLT、D-D、CD^+水平均低于对照组(P<0.05),血清25-(OH)D、SOD、CD3^+、CD4^+、CD4^+/CD8^+水平均高于对照组(P<0.05)。两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论:肠炎康颗粒治疗溃疡性结肠炎的疗效可靠,可调节血清TNF-α、25-(OH)D、YKL-40分泌,缓解氧化应激损伤,改善血液高凝、免疫功能紊乱状态。Objective：To research the effect of changyankang granules on the tumor necrosis factor-αt（tnf-α）,25-hydroxyl vitamin d （25-（oh）·d）,chitin enzyme protein 40（ykl-40） levels of patients with ulcerative colitis.Methods：98 patients with ulcerative colitis with reference the stochastic indicator method divided into control group （n=49） and research group （n=49）,the control group was treated with routine treatment,the research group based on the control group with changyankang granule treatment,the curative effect,the changes of serum TNF-α,25-（OH）D,YKL-40,propanediol （MDA）,superoxide disproportionation alcohol （SOD）,platelet count （PLT）,D-dimer （D-D）,CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋ levels and the occurrence of adverse reactions of two groups were compared before and after the treatment.Results：After the treatment,the total effective rateof research group was higher than the control group,the difference was statistically significant （P〈0.05）.the serum of TNF-α,YKL-40,MDA,PLT,D-D,CD8^＋ levels in research group was lower than the control group （P〈0.05）.The serum 25-（OH）D,SOD,CD3^＋,CD4^＋,CD4^＋/CD8^＋ levels in research group were higher than those of the control group （P〈0.05）.No significant difference was found in the adverse reactions between the two groups （P〉0.05）.Conclusion：Changyankang granules was effective in the treatment of ulcerative colitis,which could adjust the secretion of TNF-α,25-（OH） D,YKL-40 relieve oxidative stress damage,improve the high blood coagulation and immune dysfunction.

关 键 词：溃疡性结肠炎 肠炎康颗粒 疗效 肿瘤坏死因子-α 25-羟维生素D 甲壳质酶蛋白40 

分 类 号：R574.62[医药卫生—消化系统]