甲状腺癌诊断及预后相关分子标志物的研究进展  

Progress in Molecular Markers of Thyroid Cancer Diagnosis, Prognosis

作　　者：梅志丹[1] 陈晨[1] 胡章威 郑安元 陶泽璋[1] 

机构地区：[1]武汉大学人民医院耳鼻喉头颈外科,湖北武汉430060

出　　处：《现代生物医学进展》2017年第18期3592-3595,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81372880);高等学校博士学科点专项科研基金项目(20130141120093);湖北省自然科学基金项目(2012FFA045)

摘　　要：甲状腺结节是最常见的疾病之一,其精确诊断对于患者的有效临床管理十分重要。分子标志物是一项非常有效的诊断和预后评估工具,尤其在细胞学不确定的甲状腺癌结节。近年来,分子标志物的临床应用发展已经取得显著的进步。随着新一代基因检测技术的发展,能够同时检测多个基因,这不仅可为甲状腺癌的诊断提供依据,而且也可为预测甲状腺癌患者的预后提供参考,本文就甲状腺癌的诊断及预后相关的分子标志物进行综述。Thyroid nodules are common,and the accurate diagnosis of Thyroid nodules is important for the effective clinical management of patients.Molecular markers are a helpful diagnostic and prognosis evaluation tool,particularly for cytologically indeterminate thyroid nodules;In recent years,significant progress has been made in developing molecular markers for clinical use.With the development of next generation sequencing technology,multiple genes can be detected,which not only can provide the basis for diagnosis of thyroid cancer,but also providing reference for predicting the prognosis of patients with thyroid cancer.In this review,we summarize the Progress in Molecular Markers of Thyroid Cancer Diagnosis,Prognosis.

关 键 词：甲状腺癌 分子标志物 肿瘤 靶向治疗 

分 类 号：R736.1[医药卫生—肿瘤]