联合检测E-cadherin,VEGF表达水平在卵巢良恶性肿瘤诊断中的临床价值  

Clinical Value of Combined Detection of E-cadherin and VEGF in Diagnosis of Ovarian Benign and Malignant Tumors

作　　者：唐晓梅[1] 刘坦坦[2] 张红娟[2] 王三喜[1] 敬源 TANG Xiao-mei LIU Tan-tan ZHANG Hong-juan WANG San-xi JING Yuan(Pathology Department, Baoji People＇s Hospital of Shaanxi Province, Baoji, Shaanxi, 721000, China PathologyDepartment, The Fourth MilitaryMedical UniversityAfSliated Xijing Hospital, Xi＇an, Shaanxi, 710032, China Gynecology Departrneng Baoji People＇s Hospital of Shaanxi Province, Baoji, Shaanxi, 721000, China)

机构地区：[1]陕西省宝鸡市人民医院病理科,陕西宝鸡721000 [2]第四军医大学附属西京医院病理科,陕西西安710032 [3]陕西省宝鸡市人民医院妇科,陕西宝鸡721000

出　　处：《现代生物医学进展》2017年第20期3897-3900,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨联合检测E-钙粘素(E-cadherin)、血管内皮生长因子(VEGF)表达水平在卵巢良恶性肿瘤诊断中的临床价值。方法:收取2012年1月至2016年1月间我院收治的卵巢良恶性肿瘤患者共83例,使用免疫组化方法检测对E-cadherin及VEGF表达情况进行分析与比较。结果:E-cadherin在卵巢良性肿瘤、卵巢交界性肿瘤及卵巢恶性肿瘤中的阳性表达率分别为64.71%、44.44%及25.00%,VEGF在卵巢良性肿瘤、卵巢交界性肿瘤及卵巢恶性肿瘤中的阳性表达率分别为11.76%、33.33%及83.33%,上述差异均具有统计学意义(P<0.05)。E-cadherin及VEGF在卵巢恶性肿瘤中的表达与分化程度、FIGO分期有关(P<0.05)。VEGF表达与淋巴结转移有关(P<0.05),但E-cadherin与淋巴结转移关系不大(P>0.05)。E-cadherin及VEGF表达呈负相关(r=-0.472,P<0.05)。结论:E-cadherin低表达及VEGF高表达与卵巢恶性肿瘤发生、发展及侵袭有密切关系。Objective：To explore the clinical value of combined detection of E-cadherin and VEGF in the diagnosis of ovarian benign and malignant tumors.Methods：83 patients with ovarian benign and malignant tumor accepted in our hospital from January 2012 to January 2016 were selected.And the expression level of E-cadherin and VEGF were tested by immunohistochemistry and compared between two groups.Results：The positive expression rate of E-cadherin of ovarian benign tumor,borderline tumor and malignant tumor was 64.71％,44.44 ％ and 25.00 ％ respectively.The positive expression rate of VEGF of ovarian benign tumor,borderline tumor and malignant tumor was 11.76 ％,33.33 ％ and 83.33 ％ respectively.There was statistically difference between them （P＜0.05）.The expression level of E-cadherin and VEGF in ovarian malignant tumor had correlation with degrees of pathological differentiation and FIGO stage （P＜0.05）.The expression of VEGF had correlation with lymph node metastasis （P＜0.05）,but E-cadherin had no correlation with it （P＞0.05）.There was a negative correlation between E-cadherin and VEGF （r=-0.472,P＜0.05）.Conclusions：The low expression of E-cadherin and high expression of VEGF has a close relation with the occurrence,development and invasion of ovarian malignant tumor.

关 键 词：卵巢良恶性肿瘤 E-钙粘素 血管内皮生长因子 诊断 

分 类 号：R737.31[医药卫生—肿瘤]