奥沙利铂联合5-氟尿嘧啶对食管癌患者血清IGF-1及TGF-β_1水平的影响  

Effects of Oxaliplatin and 5-Fluorouracil on Serum Levels of IGF-1 and TGF-β_1 in Patients with Esophageal Carcinoma

作　　者：江波[1] 周伟[1] 龙翔宇[1] 朱其荣[2] 应伟[1] JIANG Bo ZHOU Wei LONG Xiang-yu ZHU Qi-rong Y(Department of oncology, Guang＇an hospital, Guang＇an, Sichuan, 638000, China Department of Infection, AflYliated hospital ofNorth Sichuan medical college, Nanchong, Sichuan, 637000, China)

机构地区：[1]四川大学华西广安医院肿瘤科,四川广安638000 [2]川北医学院附属医院感染科,四川南充637000

出　　处：《现代生物医学进展》2017年第20期3940-3943,共4页Progress in Modern Biomedicine

基　　金：四川省卫生厅基金项目(981023)

摘　　要：目的:研究奥沙利铂联合5-氟尿嘧啶对食管癌患者的治疗效果及对血清胰岛素样生长因子1(IGF-1)及转化生长因子β(TGF-β_1)的影响。方法:选取2014年9月至2015年8月本院收治的78例食管癌患者,根据随机数字法分为观察组和对照组,39例每组。观察组采取奥沙利铂联合5-氟尿嘧啶进行治疗,对照组采取顺铂联合5-氟尿嘧啶进行治疗。比较两组患者治疗前后IGF-1、TGF-β_1水平变化,分析两组患者临床疗效和不良反应。结果:治疗后,观察组总缓解率显著高于对照组(P<0.05);两组患者IGF-1、TGF-β_1水平较治疗前显著降低(P<0.05),观察组IGF-1、TGF-β_1水平低于对照组(P<0.05);两组患者白细胞降低、血小板减少、贫血、脱发、神经感觉障碍、神经运动障碍不良反应率比较,差异无统计学意义(P>0.05);观察组患者恶心呕吐、口腔炎、腹泻等不良反应发生率均低于对照组(P<0.05)。结论:奥沙利铂联合5-氟尿嘧啶方治疗食管癌的临床疗效显著,能够有效降低患者血清TGF-β_1及IGF-1水平,且不良反应少,安全性高。Objective：To study the effect of oxaliplatin combined with 5-fluorouracil on serum levels of insulin-like growth factor-1 （IGF-1） and transforming growth factor-β1 （TGF-β0 of patients with esophageal cancer.Methods：78 patients with esophageal cancer who were treated in our hospital from September 2014 to August 2015 were selected and randomly divided into the observation group and the control group with 39 cases in each group.The patients in the observation group were treated with oxaliplatin and 5-fluorouracil,and the patients in the control group were treated with cisplatin combined with 5-fluorouracil.Then the serum levels of IGF-1 and TGF-β,the clinical efficacy and adverse reactions in the two groups were observed and compared before and after the treatment.Results：After treatment,the total remission rate in the observation group was significantly higher than that of the control group （P＜0.05）.After treatment,the serum levels of IGF-1 and TGF-β31 in the two groups were significantly lower than before （P＜0.05）.The serum levels oflGF-1 and TGF-β1 in the observation group were significantly lower than those of the control group （P＜0.05）.There was no significant difference in the incidence of eukopenia,thrombocytopenia,anemia,alopecia,neurosensory disorder and neuromotor disorder between the two groups （P＞0.05）.The adverse reactions of nausea,vomiting,stomatitis and diarrhea in the observation group were significantly lower than those of the control group （P＜0.05）.Conclusion：Oxaliplatin combined with 5-fluorouracil regimen can reduce the serum levels of TGF-β1 and IGF-1 in patients with esophageal cancer,with obvious clinical efficacy and safety.

关 键 词：奥沙利铂 5-氟尿嘧啶 食管癌 胰岛素样生长因子1 转化生长因子Β1 

分 类 号：R735.1[医药卫生—肿瘤]