银杏达莫对急性脑梗死患者t-PA,Hcy,MMP-9的影响  

Curative Efficacy of Ginkgo-damo on Acute Cerebral Infarction and Serum Levels of t-PA, Hcy and MMP-9

作　　者：师仰宏[1] 霍艳艳[1] 黄苗[1] 薛瑶[1] 封婷[2] SHI Yang-hong HUO Yan-yan HUANG Miao XUE Yao FENG Ting(Second Deparment of Neurology, Yulin First Hospital, Yulin, Shaanxi, 719000, China Department of Neurology, the Second Affiliated Hospital of Yan＇an University, Yah＇an, Shaanxi, 719000, China)

机构地区：[1]陕西省榆林市第一医院神经内二科,陕西榆林719000 [2]延安大学第二附属医院神经内科,陕西延安719000

出　　处：《现代生物医学进展》2017年第20期3944-3947,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(C2009jB090)

摘　　要：目的:研究银杏达莫治疗急性脑梗死的临床疗效及其对患者血清纤维蛋白溶煤原活化剂(t-PA)、同型半胱氨酸(Hcy)、基质金属蛋白酶9(MMP-9)水平的影响。方法:选取2014年3月至2015年3月我院接诊的急性脑梗死患者90例为研究对象并将其随机分为两组。对照组采用常规治疗,观察组采用银杏达莫治疗,观察和比较两组患者治疗后血清t-PA、Hcy、MMP-9水平,神经功能缺损(NIHSS)评分,Barthel指数、脑血流变化和临床疗效。结果:治疗后,观察组总有效率[95.55%(43/45)]显著高于对照组[71.11%(32/45)](P<0.05),NIHSS评分低于对照组[(2.83±0.51)%vs(6.91±1.21)%],Barthel指数大于对照组[(82.10±4.03)%vs(64.86±5.39)%](P<0.05),血清t-PA水平显著高于对照组[(0.59±0.16)IU·mL^(-1) vs(0.52±0.14)IU·mL^(-1)],血清Hcy、MMP-9水平明显低于对照组[(10.49±1.97)ng/L vs(15.92±2.01)ng/L、(16.35±1.30)mol/L vs(21.54±2.53)mol/L、(159.07±14.53)pg/mL vs(231.34±16.72)pg/mL](P<0.05);观察组MCA、PCA显著大于对照组[(49.40±6.30)cm2 vs(41.36±5.76)cm2、(34.86±4.29)cm2 vs(29.76±4.20)cm2](P<0.05)。结论:银杏达莫治疗急性脑梗死的临床疗效显著,能够促进神经功能恢复,改善血管内皮功能,降低Hcy、MMP-9水平,有利于患者的预后。Objective：To study curative efficacy of ginkgo-damo in treatment of acute cerebral infarction and its effects on patients with Tissue-type plasminogen activator（t-PA）,homocysteine （Hcy）,Matrix metalloproteinase-9（MMP-9）.Methods：90 patients of acute cerebral infarction who received therapy from March 2014 to March 2015 in our hospital were selected as research objects.According to random number table,those patients were divided into two group The control group was treated with routine treatment,while the observation group was treated with ginkgo-damo.Then T-PA,Hcy,MMP-9,National Institute of Health stroke scale （NIHSS） score,Barthel index,Cerebral blood flow changes curative effect two groups before and after treatment were compared.Results：After treatment,the total effective rate in the observation group[95.55％（43/45）] was significantly higher than the control group[71.11％（32/45）] （P＜0.05）,NIHSS score was less than the control group [（2.83± 0.51）％ vs （6.91± 1.21）％],Barthel index was than the control group [（82.10± 4.03）％ vs（64.86± 5.39）％] （P＜0.05）,serum t-PA level was significantly higher than that of the control group[（0.59± 0.16） IU·mL-1 vs （0.52± 0.14）IU·mL1],serum Hcy,MMP-9 level was significantly lower than those of control group [（10.49± 1.97）ng/L vs （15.92± 2.01）ng/L,（16.35± 1.30）rmol/L vs （21.54± 2.53）mol/L,（159.07± 14.53）pg/mL vs （231.34± 16.72）pg/mL]（P＜0.05）;MCA,PCA was significantly higher than the control group [（49.40± 6.30）em2 vs （41.36 ± 5.76）cm2,（34.86± 4.29）cm2 vs （29.76± 4.20）cm2] （P＜0.05）.Conclusion：Ginkgo-damo is well for acute cerebral infarction,which can promote the recovery of nerve function,improve the vascular endothelial function,decrease the level of Hcy and MMP-9,which is beneficial to the prognosis of patients.

关 键 词：银杏达莫 急性脑梗死 血清纤维蛋白溶煤原活化剂 同型半胱氨酸 基质金属蛋白酶9 

分 类 号：R743[医药卫生—神经病学与精神病学]