坦度螺酮治疗伴有焦虑抑郁的功能性消化不良的疗效及对生存质量的影响  

Efficacy of tandospirone in treating functional dyspepsia accompanied by anxiety and depression and its influence on quality of life

作　　者：龚晓兵[1] 李淑珍[1] 黄叶盛 马彦[1] 柳永刚 蒋亚斌[2] 杨见权[1] GONG Xiaobing LI Shuzhen HUANG Yesheng MA Yan Yabin YANG Jianquan LIU Yonggang JIANG(Department of Gastroenterology Department of Emergency Medicine, the First Affiliated Hospital of finan University, Guangzhou 510630, Guangdong , China)

机构地区：[1]暨南大学附属第一医院消化内科 [2]暨南大学附属第一医院急诊科

出　　处：《中国临床药理学与治疗学》2017年第6期664-667,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(31170941;81671946);广东省医学科学技术研究基金(A2015479)

摘　　要：目的:观察坦度螺酮治疗伴有焦虑抑郁的功能性消化不良(FD)的临床疗效及对生存质量的影响。方法:将98例伴有焦虑抑郁的FD患者随机分为治疗组和对照组,每组49例。对照组给予泮托拉唑和莫沙必利口服,治疗组在此基础上加用坦度螺酮口服治疗,疗程4周。观察两组临床疗效及不良反应。结果:治疗组在治疗后的FD症状、汉密顿抑郁量表(HAMD)及汉密顿焦虑量表(HAMA)评分均较治疗前显著下降(P<0.01),而功能性消化不良生存质量量表(FDDQL)评分则较治疗前明显升高,且与对照组比较差异有统计学意义(P<0.01)。治疗组的总有效率(85.7%)显著高于对照组(63.3%)(χ~2=6.49,P<0.05)。两组未见明显不良反应。结论:坦度螺酮治疗伴有焦虑抑郁的FD安全、有效,能显著改善患者的焦虑抑郁症状及生存质量。AIM： To observe the clinical efficacy of tandospirone in the treatment of functional dyspepsia（ FD） accompanied by anxiety and depression and its influence on quality of life. METHODS：Ninety-eight cases with FD accompanied by anxiety and depression were randomly divided into treatment group and control group（ n = 49）. Patients of control group were treated with oral pantoprazole and mosapride. On the basis of control group,the treatment group was given oral tandospirone for four weeks. The therapeutic effect and adverse effects were observed and compared in both groups. RESULTS：Compared with before treatment,the scores of FD symptoms,Hamilton Rating Scale for Despression（ HAMD） and Hamilton Anxiety Scale（ HAMA） in treatment group decreaed significantly after treatment,while the score of Functional DigestiveDisorders Quality of Life Questionnaire（ FDDQL）increased significantly（ all P 0. 01）; the decrease of FD symptoms,HAMD,HAMA scores and the increase of FDDQL scores of treatment group were greater than those of control group（ all P 0. 01）.The total effective rate of treatment group was significantly higher than that of control group（87. 5% vs.63. 3%,χ~2= 6. 49,P 0. 05）. There was no obvious adverse effect recurred in both groups. CONCLUSION： Tandospirone is a safe and effective drug for FD accompanied by anxiety and depression;it can effectively improve the symptoms of anxiety,depression and quality of life of patients.

关 键 词：功能性消化不良 坦度螺酮 焦虑 抑郁 生存质量 

分 类 号：R57[医药卫生—消化系统]