健脾祛湿方联合生活方式调整干预脾虚湿阻型非酒精性脂肪性肝病临床研究  

Clinical Study of Jianpi Qushi Prescription Combined with Lifestyle Adjustment for Nonalcoholic Fatty Liver Disease of Spleen Deficiency and Damp Retention Type

作　　者：孙靖若[1] 吴艾恩 

机构地区：[1]中山市博爱医院中医康复科,广东中山528403

出　　处：《新中医》2017年第7期55-57,共3页New Chinese Medicine

基　　金：中山市科技局立项课题(2015B1224)

摘　　要：目的:观察健脾祛湿方联合生活方式调整干预脾虚湿阻型非酒精性脂肪性肝病(NAFLD)的临床疗效。方法:将120例脾虚湿阻型NAFLD患者随机分为治疗组和对照组各60例,对照组给予基础运动和生活指导等生活方式调整,治疗组在生活方式调整基础上给予健脾祛湿方。2组均以3月为1疗程,3月后比较2组的治疗效果,观察治疗前后中医证候积分、肝功能指标和血脂指标、肝脏B超结果等变化。结果:治疗后,总有效率治疗组93.33%,对照组61.67%,2组比较,差异有统计学意义(P<0.01)。2组胁痛、体倦乏力、脘闷腹胀、食少纳呆积分均较治疗前下降,差异均有统计学意义(P<0.01,P<0.05);治疗组以上4项积分均低于对照组,差异均有统计学意义(P<0.05)。2组总胆固醇(TC)、甘油三酯(TG)、谷丙转氨酶(ALT)、谷草转氨酶(AST)水平均较治疗前下降,差异均有统计学意义(P<0.01,P<0.05);治疗组TC、TG、ALT、AST水平均低于对照组,差异均有统计学意义(P<0.05)。2组超声结果均较治疗前改善,差异均有统计学意义(P<0.05);2组超声结果比较,差异有统计学意义(P<0.05)。结论:采用健脾祛湿方联合生活方式调整干预脾虚湿阻型NAFLD患者能够缓解脂肪肝的各种症状,减轻脂肪肝的病变程度,具有较好的临床疗效。Objective： To observe the clinical effect of Jianpi Qushi prescription combined with lifestyle adjustment for nonalcoholic fatty liver disease（NAFLD） of spleen deficiency and damp retention type. Methods： Divided 120 cases of NAFLD patients of spleen deficiency and damp retention type into the treatment group and the control group randomly, 60 cases in each group. Both groups received basic exercise, life guidance and other lifestyle adjustment, while the treatment group was additionally treated with Jianpi Qushi prescription. Both groups received treatment for three months as one course. After three months of treatment, compared the curative effect, and observed Chinese medicine syndrome score, liver function index and change of blood fat index and liver B-ultrasound result in both groups before and after treatment. Results： After treatment, the total effective rate was 93.33% in the treatment group and was 61.67% in the control group, the difference being significant（P〈0.01）. Scores of hypochondriac pain, fatigue, expanding of abdomen and anorexia in both groups were decreased when compared with those before treatment（P〈0.01, P〈0.05）, and the above four scores in the observation group were all lower than those in the control group（P 〈 0.05）. Levels of total cholesterol （TC）, triglyceride （TG）, alanine aminotransferase （ALT） and aspartate aminotransferase （AST） in both groups were declined, comparing with those before treatment（P〈 0.01, P〈 0.05）. Levels of TC, TG, ALT and AST in the treatment group were all lower than those in the control group（P〈 0.05）. Comparing with those before treatment, liver B-ultrasound results in both groups after treatment were both improved （P 〈0.05）. The comparison of liver B-ultrasound results between two groups showed significance （P 〈0.05）. Conclusion： The therapy of Jianpi Qushi prescription combined with lifestyle adjustment for NAFLD of spleen deficiency and damp retention type can relieve many symptoms a

关 键 词：非酒精性脂肪性肝病(NAFLD) 脾虚湿阻型 健脾祛湿方 生活方式调整 肝功能 血脂 中医证候积分 

分 类 号：R575[医药卫生—消化系统]