CT灌注成像胶对质瘤患者诊断及分型的价值  

The value of CT perfusion imaging in diagnosis and classification of gliomas

作　　者：王毓佳[1] 冯晓荣[1] 赵均雄[1] 曾苗雨[1] 

机构地区：[1]深圳市福田区人民医院医学影像科,广东深圳518033

出　　处：《现代肿瘤医学》2017年第15期2488-2491,共4页Journal of Modern Oncology

摘　　要：目的:探讨对CT灌注成像胶质瘤患者诊断及分型的价值。方法:采用回顾性研究方法,2013年2月至2016年1月选择在我院神经外科诊治的胶质瘤患者88例,包括低分型胶质瘤(低分型组)48例和高分型胶质瘤(高分型组)40例。两组都进行常规CT与CT灌注成像诊断分析,同时进行VEGF免疫组化染色分析与相关性分析。结果:胶质瘤CT常规成像显示瘤体形态不规则,低分型组多表现为不规则片状强化和轻度水肿,高分型组多表现为环形强化,水肿呈现指压状。高分型组的CBF、CBV、MTT与PS值都明显高于低分型组,对比差异都有统计学意义(P<0.05)。高分型组的VEGF阳性率为92.5%,而低分型组为58.3%,高分型组明显高于低分型组(P<0.05)。Spearman分析发现胶质瘤CT对CBV、CBF、MTT灌注和PS值、VEGF阳性表达间有着明显的关系(r=0.563,0.622,0.582,0.602,P均<0.05)。结论:可以通过CT灌注成像判断胶质瘤分型,也能对肿瘤血供及血管情况情况进行判断,从而有利于预测患者预后,指导选择合理的治疗方法。Objective： To investigate the value of CT perfusion imaging in diagnosis and classification of gliomas.Methods： Used the retrospective study method,88 cases of glioma were selected that included low gliomas（ low group） 48 cases and high glioma（ high group） 40 cases. Patients in two groups were given conventional CT and CT perfusion imaging analysis and diagnosis,and were given the VEGF immunohistochemical analysis. Results： Conventional CT imaging display tumor glioma were more with irregular shape,low group were more irregular patchy enhancement and mild edema and high group were more ring enhancement and the finger shaped edema. The CBF,CBV,MTT and PS values in the high group were significantly higher than the low group（ P〈 0. 05）. The positive rate of VEGF in the high group was 92. 5%,while the low group was 58. 3%（ P〈 0. 05）. Spearman correlation analysis showed that CT,CBV,MTT,CBF and PS were significantly positively correlated with VEGF positive expression（ r = 0. 563,0. 622,0. 582,0. 602,P〈 0. 05）. Conclusion： CT perfusion imaging can provide valuable information for the diagnosis of glioma,and it can also evaluate the blood supply and blood vessels of the tumor,so as to predict the prognosis of patients,and guide the selection of reasonable treatment methods.

关 键 词：胶质瘤 CT灌注成像诊断 临床分型 肿瘤血供 

分 类 号：R730.264[医药卫生—肿瘤]