奈达铂与顺铂联合同期调强治疗对鼻咽癌的疗效  

Effect of Nedaplatin and Cisplatin Combined Simultaneous Intensity-modulated Therapy in the Treatment of Nasopharyngeal Carcinoma

作　　者：张钦华[1] 邹雨荷[1] 李坊铭[1] 丁小凡[1] ZHANG Qinhua ZOU Yuhe LI Fangming DING Xiaofan(Department of Oncology, Jiangmen Central Hospital, Jiangmen 529000, G uangdong, Chin)

机构地区：[1]江门市中心医院肿瘤科,广东江门529000

出　　处：《贵州医科大学学报》2017年第7期859-862,共4页Journal of Guizhou Medical University

摘　　要：目的:探讨奈达铂与顺铂同期调强放疗治疗鼻咽癌的疗效、不良反应及生活质量。方法:选取90例鼻咽癌患者,随机分为奈达铂组(n=41)与顺铂组(n=49),两组均采用调强放射治疗,在此基础上奈达铂组给予100 mg/m2奈达铂静脉滴注,顺铂组给予50 mg/m2顺铂静脉滴注;观察两组患者治疗后3个月疗效及在恶心、呕吐及食欲减退、血小板减少、血红蛋白下降、白细胞减少等方面的不良反应程度;采用SF-36量表评估两组患者治疗前躯体角色功能、总体健康、社会功能、情绪角色功能和心理健康等各维度的生活质量情况。结果:奈达铂组与顺铂组鼻咽肿瘤完全缓解分别为37例和41例,部分缓解分别为4例和8例,有效率均为100%,两组疗效比较差异无统计学意义(P>0.05);顺铂组在恶心、呕吐及食欲减退的不良反应程度明显强于奈达铂组,差异有统计学意义(P<0.05);两组血小板减少、血红蛋白下降、白细胞减少等不良反应程度比较差异无统计学意义(P>0.05);顺铂组治疗后躯体角色功能、总体健康、社会功能、情绪角色功能和心理健康等维度较治疗前有所改善(P<0.05);奈达铂组治疗后躯体机能、躯体角色功能、总体健康、社会功能、情绪角色功能和心理健康等维度较治疗前有所改善,差异有统计学意义(P<0.05);奈达铂组治疗后躯体机能、躯体角色功能、社会功能、情绪角色功能得分明显好于顺铂组,差异有统计学意义(P<0.05)。结论:奈达铂联合同期调强治疗和顺铂联合同期调强治疗鼻咽癌的疗效相似,但奈达铂引起的胃肠道不良反应轻,且患者生活质量较好。Objective： To investigate efficacy and adverse reactions of nedaplatin and cisplatin con- current intensity-modulated radiotherapy for nasopharyngeal carcinoma. Methods： Ninety cases of nasopharyngeal carcinoma in our hospital were chosen and randomly divided into nedaplatin group （n = 41, group N） and cisplatin group （n =49, group C）, Based on intensity modulated radiation therapy, group N received 100mg/m2 nedaplatin intravenous infusion, and group C received 50mg/m2intrave- nous infusion of cisplatin. The 3-mounths curative effect and adverse reactions in nausea, vomiting, anorexia, thrombocytopenia, hemoglobin depletion, and leukocyte depletion were observed in the two groups; SF-36 scales were used to assess the quality of life of the two groups before and after treat- ment, such as body function, general health, social function, emotional role, mental health and other dimensions. Results： The tumor complete remission in group N and group C were 37 cases and dl ca- ses, and partial remission were 4 cases and 8 cases respectively, The effective rate was 100%. There was no statistically significant difference in the efficacy between the two groups （P 〉 0.05 ） ; The de- gree of adverse reactions of nausea, vomiting and anorexia in group C was significantly higher than that in group N （ P 〈 0.05 ） ; The differences of platelet reduction, hemoglobin decrease and white blood cell decrease were not significant between the two groups, （ P 〉0.05） ; After treatment physical role function, general health, social function, emotional role function and mental health dimensions were improved in group C than before （P 〈 0.05 ） ; After treatment, body function, physical role function, general health, social function, emotional role function and mental health dimensions in group N were improved than before （ P 〈 0.05 ） ; In group N, after treatment, physical function, physical role tunction, social function, emotional role function score were significantly better than those in group

关 键 词：鼻咽肿瘤 药物疗法 联合 顺铂 奈达铂 

分 类 号：R734.1[医药卫生—肿瘤] R765.2[医药卫生—临床医学]