复方丹参片联合抗癫痫药物治疗学龄期儿童癫痫的疗效及对血清NSE、IL-6和hs-CRP及认知功能的影响  

Effect of compound Danshen tablet combined with antiepileptic drugs on epilepsy in school-age children and on their serum NSE,IL-6,hs-CRP and cognitive function

作　　者：张桐 ZHANG Tong(Xuzhou Children＇ s Hospital, Xuzhou 221000, Jiangsu, China)

机构地区：[1]江苏省徐州市儿童医院,江苏徐州221000

出　　处：《现代中西医结合杂志》2017年第23期2538-2540,2601,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察复方丹参片联合抗癫痫药物治疗学龄期癫痫患儿的临床疗效及对血清神经元特异性烯醇化酶(NSE)、白细胞介素-6(IL-6)和超敏C反应蛋白(hs-CRP)水平及认知功能的影响。方法将92例学龄期癫痫患儿随机分为观察组47例和对照组45例,对照组给予丙戊酸钠治疗,观察组在对照组治疗基础上给予复方丹参片治疗,疗程12周。观察2组治疗前后血清NSE、IL-6和hs-CRP水平和认知功能变化情况,并统计2组疗效。结果观察组治疗后的总有效率显著高于对照组(P<0.05);2组治疗后血清NSE、IL-6和hs-CRP水平均较治疗前显著降低(P均<0.05),且观察组上述指标改善情况优于对照组(P均<0.05);观察组治疗后WAIS-RC及WMS-RC中的语言智商、操作智商、总智商和记忆商评分均有升高(P均<0.05),而对照组上述评分均有不同程度的降低,且观察组上述评分高于对照组(P均<0.05)。2组治疗期间均未发现严重药物不良反应。结论在抗癫痫药物治疗的基础上应用复方丹参片治疗能够显著抑制患儿血清NSE、IL-6和hs-CRP水平,具有一定的脑保护效应,且能够改善患儿的认知功能,安全可靠。Objective It is to observe the effect compound Danshen tablet combined with antiepileptic drugs on epilepsy in school-age children and on their serum neuron specific euolization enzyme （NSE） , interleukin 6 （ IL-6）, hypersensitive C-reactive protein （hs-CRP） and cognitive function. Methods 92 cases of school-age children with epilepsy were randomly divided into observation group （47 cases） and control group （45 cases）. The control group was treated with sodium valproic acid, while the observation group was treated with compound Danshen tablets on the basis of treatment in control group, the treatment course was 12 weeks. The changes of levels of serum NSE, IL-6 and hs-CRP and the cognitive function before and after treatment were observed in the two groups, and the therapeutic effects were statistically analyzed. Results The total effective rate after treatment was significantly higher in observation group than that in the control group （ P 〈 0, 05 ）. After treatment, the levels of serum NSE, IL-6 and hs-CRP were significantly reduced compared with that before treatment in both groups（P 〈 0.05） , and the improvements of these indexes in the observation group were better than that in the control group （ P 〈 0.05）. In observation group after treatment, the scores of WAIS-RC and WMS-RC such as language of intelligence quotient, operation intelligence quotient, total intelligence quotient and memory quotient were increased （ P 〈 0.05 ）, but the scores were decreased more or less in control group（P 〈 0.05 ）, and the scores in observation group were higher than that in control group （ P 〈 0. 05 ）. No serious adverse drug reactions was found during treatment in the two groups. Conclusion Compound Danshen injection on the basis of antiepileptic drug therapy can significantly inhibit the levels of serum NSE, IL-6 and hs-CRP, has certain protective effect, and can improve cognitive function in children with epilepsy, it is safe and reliable.

关 键 词：复方丹参滴丸 丙戊酸钠 癫痫 学龄期儿童 

分 类 号：R742.1[医药卫生—神经病学与精神病学]