E-cadherin蛋白与胰腺癌发病风险相关性的Meta分析  

Correlation of E-cadherin protein expression and the risk of pancreatic cancer:a meta-analysis

作　　者：李月[1] 李锐[2] 田文广[3] 何平[1] LI Yue LI Rui TIAN Wenguang HE Ping(Department of Gastroenterology, Yongchuan Hospital of Chongqing Medical University, Yongchuan, 402160, P.R.China Department of Oncology, Yongchuan Hospital of Chongqing Medical University, Yongchuan, 402160, P.R.China Department of Infectious Diseases, Yongchuan Hospital of Chongqing Medical University, Yongchuan, 402160, P.R.China)

机构地区：[1]重庆医科大学附属永川医院消化内科,重庆永川402160 [2]重庆医科大学附属永川医院肿瘤科,重庆永川402160 [3]重庆医科大学附属永川医院感染科,重庆永川402160

出　　处：《中国循证医学杂志》2017年第7期760-767,共8页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价E-cadherin蛋白的表达与胰腺癌发病风险的相关性。方法计算机检索Pub Med、EMbase、The Cochrane Library、CNKI、VIP、CBM和Wan Fang Data数据库,搜集2016年10月1日前国内外公开发表的关于E-cadherin蛋白的表达与胰腺癌发病风险相关性的病例-对照研究。由2名研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Rev Man 5.2和Stata 12.0软件进行Meta分析。结果最终纳入17个病例-对照研究,包括胰腺癌组986例,癌旁正常组织组433例。Meta分析结果显示:(1)E-cadherin蛋白表达在胰腺癌组低于癌旁正常组织组[OR=0.04,95%CI(0.01,0.23),P=0.000 2],在低分化组低于高中分化组[OR=0.44,95%CI(0.26,0.76),P=0.003],在伴淋巴结转移组低于无淋巴结转移组[OR=0.50,95%CI(0.31,0.81),P=0.005],其差异均有统计学意义。(2)E-cadherin蛋白表达在Ⅰ~Ⅱ期组与Ⅲ~Ⅳ期[OR=0.63,95%CI(0.25,1.59),P=0.33],胰头癌组与胰体尾癌组[OR=1.22,95%CI(0.72,2.07),P=0.46],伴神经侵犯组与无神经侵犯组[OR=1.45,95%CI(0.81,2.62),P=0.21],伴血管侵犯组与无血管侵犯组[OR=0.55,95%CI(0.13,2.22),P=0.40]的差异无统计学意义。结论 E-cadherin蛋白的低表达与胰腺癌发病风险明显相关。受纳入研究的数量和质量的限制,上述结论尚需开展更多研究予以证实。Objective To systematically review the expression of E-cadherin protein and the risk of pancreatic cancer. Methods We searched PubMed, EMbase, The Cochrane Library, CNKI, VIP, CBM and WanFang Data from inception to October 2016 to collect case-control studies about the correlation between E-cadherin protein expression and the risk of pancreatic cancer. Two reviewers independently screened the literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed using RevMan 5.2 software and Stata 12.0 software. Results Seventeen studies （986 cases in pancreatic cancer group and 433 cases in normal pancreatic tissue group） were finally included. The results of meta-analysis showed that： the expression of E-cadherin protein in the pancreatic cancer group was lower than normal tissue group （OR=0.04, 95%CI 0.01 to 0.23, P=0.000 2）, poor differentiation group was lower than high or middle differentiation group （OR=0.44, 95%CI 0.26 to 0.76, P=0.003）, lymph node metastasis group was lower than without lymph node metastasis group （OR=0.50, 95% CI 0.31 to 0.81, P=0.005）, and the difference was statistically significant. However, there was no significant difference between the clinical stage Ⅰ-Ⅱ group and Ⅲ-Ⅳ group （OR=0.63, 95%CI 0.25 to 1.59, P=0.33）, pancreatic head cancer group and pancreatic body and tail cancer group （OR=1.22, 95%CI 0.72 to 2.07, P=0.46）, pancreatic cancer with nerve invasion group and without nerve invasion group （OR=1.45, 95%CI 0.81 to 2.62, P=0.21）, pancreatic cancer with vascular invasion group and without vascular invasion group （OR=0.55, 95%CI 0.13 to 2.22, P=0.40）. Conclusion Lower expression of E-cadherin protein is significantly associated with the risk of pancreatic cancer. Due to the limited quality and quanity of includied studies, the above conclusion should be approved by more studies.

关 键 词：胰腺癌 E-CADHERIN 系统评价 META分析 病例-对照研究 

分 类 号：R735.9[医药卫生—肿瘤]