食管癌患者外周血红细胞分布宽度检测的临床价值  

Clinical significance of preoperative red blood cell distribution width in peripheral blood of patients with esophageal cancer

作　　者：韩福燕 成士清[1] 王召宝 鞠瑛[1] HAN Fuyan CHENG Shiqing WANG Zhaobao JU Ying(Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China)

机构地区：[1]山东大学附属省立医院检验科,山东济南250021

出　　处：《山东大学学报（医学版）》2017年第7期67-72,共6页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金(81000731;81202307);山东省优秀中青年科学家科研奖励基金(BS2010YY045)

摘　　要：目的探讨食管癌患者外周血红细胞分布宽度(RDW)检测的临床价值。方法回顾性分析山东大学附属省立医院在2010年7月~2011年6月接受根治性手术切除的284例食管癌患者的临床资料。收集125例健康志愿者作为对照进行对比分析;采用受试者工作特征曲线(ROC曲线)确定RDW最佳截断点,将患者分为高RDW组和低RDW组,比较两组间的临床病理参数;采用Logistic回归分析与RDW增高有关的临床病理参数;分析手术治疗前后RDW值变化。结果食管癌组患者RDW的中位数显著高于健康对照组(P<0.001);RDW与食管癌组患者性别、年龄、远处转移和肿瘤分期有关(P<0.05),而与其他病理参数无关(P>0.05);Logistic回归分析发现高龄和远处转移与RDW升高有关(P<0.05);手术治疗后RDW的值高于治疗前,差异有统计学意义。结论RDW可作为食管癌患者临床诊断及病情评估的指标。Objective To evaluate the clinical significance of preoperative red blood cell distribution width （RDW） in the peripheral blood of patients with esophageal cancer. Methods Clinical data of 284 patients with esophageal cancer undergoing radical resection during July 2010 and June 2011 were retrospectively analyzed. Another 125 healthy volun- teers were collected as controls for comparative analysis. The patients were divided into high and low RDW groups ac- cording to RDW cut-off value based on receiver operating characteristic curve （ROC）. The clinicopathological parame- ters were compared between the two groups. The parameters associated with increased RDW were analyzed using Logis- tic regression analysis. The RDW changes before and after surgery were evaluated. Results The median RDW value was significantly higher in the esophageal cancer group than in healthy control group （ P 〈 0. 001 ）. RDW was associated with age, gender, distance metastasis and tumor stage （ P 〈 0.05 ）, but not with other pathological parameters （ P 〉 0.05）. Logistic regression analysis revealed that old age and distance metastasis were significantly associated with in- creased RDW （ P 〈 0.05 ）. The RDW value after surgery was significantly higher than that before surgery and the difference was statistically significant. Conclusion RDW can be used as an indicator of clinical diagnosis and condi- tion assessment for patients with esophageal cancer.

关 键 词：食管癌 红细胞分布宽度 临床病理参数 治疗前后 

分 类 号：R735.1[医药卫生—肿瘤]