PRL-3在肿瘤中作用机制的研究进展  

Progression on the mechanism of PRL-3 in tumors

作　　者：宋秀军 刘建红 吕进 江其生 

机构地区：[1]火箭军总医院核与辐射损伤实验室,北京100088 [2]火箭军总医院礼士路门诊部,100088

出　　处：《临床肿瘤学杂志》2017年第6期566-569,共4页Chinese Clinical Oncology

基　　金：国家自然科学基金资助项目(81172130)

摘　　要：肝再生磷酸酶-3(PRL-3)是一种与肿瘤转移相关的酪氨酸磷酸酶,在多种肿瘤如急性髓性白血病、结直肠癌、乳腺癌和非小细胞肺癌中高表达,具有促进细胞增殖、迁移和侵袭的作用。近年来,随着研究手段的不断深入,对PRL-3在肿瘤中的作用机制的研究逐渐增多。研究发现PRL-3在不同肿瘤中促进肿瘤发生及转移的作用通路不尽相同,在肿瘤的靶向治疗中有广阔的临床应用前景。本文就PRL-3在肿瘤中作用机制的相关研究进展作一简要综述。Phosphatase of regenerating liver-3 （PRL-3） is a metastasis-associated phosphatase which was highly expressed in various types of cancers, such as acute myeloid leukemia, colorectal cancer, breast carcinoma, non-small cell lung cancer and so on. It can promote cell proliferation, migration and invasion. In recent years, with the development of research methods, the research on mechanism of PRL-3 in tumor is increasing. These studies found that the pathways of tumorigenesis and metastatic was not all the same in deferent tumors. So it has the wide prospect of the clinieal application in targeted therapy. This review is about the mechanism of ac- tion of PRL-3 in tumors.

关 键 词：肿瘤 肝再生磷酸酶-3 机制 

分 类 号：R730.51[医药卫生—肿瘤]