内皮功能障碍介导的恶性循环在阿尔茨海默病中的研究进展  

Research Advances of Endothelium Dysfunction Mediated Vicious Circulation in Alzheimer's Disease

作　　者：张释双[1] 支永乐[2] 雷平[1] 

机构地区：[1]天津医科大学总医院保健医疗部(老年病科),天津市老年病学研究所,天津300052 [2]天津市第三中心医院重症监护室,天津300170

出　　处：《医学综述》2017年第14期2730-2734,共5页Medical Recapitulate

基　　金：天津市卫生局科技基金(2015KZ118);天津医科大学总医院青年孵育基金(ZYYFY2015034)

摘　　要：在老龄化的中国,阿尔茨海默病(AD)已成为一个重要的公共健康问题。衰老是散发型AD的主要危险因素,近些年AD血管假说也备受瞩目。衰老和血管疾病引起的慢性脑灌注不足,直接损害脑实质细胞和血脑屏障(BBB)。BBB功能障碍促进氧化应激,炎症反应和一氧化氮失调等,间接介导了慢性脑缺血的神经毒性作用,加速神经退行性病变的进程。因此,总结AD中以血管功能障碍为基础的内皮介导机制,揭示AD病理损伤机制间的恶性循环,对于寻找新的AD治疗靶点具有重要意义。Alzheimer＇s disease （AD） has become an important public health problem in China. Aging is a major risk factor for sporadic AD and vascular hypothesis has received much attention in recent years in AD. Aging and vascular disease result in chronic cerebral hypoperfusion, directly damaging to brain parenchymal cells and blood-brain barrier（BBB）. BBB dysfunction indirectly mediates the neurotoxic effects of chronic cerebral ischemia by stimulating oxidative stress, inflammatory response, and imbalance of nitric oxide, consequently accelerating the progress of neurodegenerative diseases. Therefore,summarizing the endothelial-mediated mechanisms based on vascular dysfunction in AD, and revealing vicious circulation which can aggravate pathological damage of AD, are important to find a new therapeutic target for AD.

关 键 词：阿尔茨海默病 脑灌注不足 血脑屏障 氧化应激 内皮功能障碍 

分 类 号：R749.16[医药卫生—神经病学与精神病学]