小纤维神经病的研究进展  

Research Progress in Painful Small Fiber Neuropathy

作　　者：潘晓丽[1] 叶红莲[1] 高柏[1] 

机构地区：[1]中国医科大学附属盛京医院神经功能科,沈阳110004

出　　处：《医学综述》2017年第14期2800-2804,共5页Medical Recapitulate

摘　　要：小纤维神经病(SFN)临床上又被称为"痛性小纤维神经病"。其病因复杂,发病机制不清。临床主要以感觉异常和自主神经功能障碍为主要表现。由于常规肌电图神经传导检测多为正常。SFN早期难以诊断。如不及时进行临床干预,患者反复间断发作,神经痛逐渐恶化,甚至导致心源性猝死。诊断SFN的方法主要包括临床检查及辅助检测。临床上应用较多的辅助检测方法包括皮肤交感反应、皮肤活检、电流感觉阈值测定等。目前尚无特效治疗方法,除病因学治疗外,临床上主要是应用止痛药、抗抑郁药及理疗等方法进行对症治疗。Small fiber neuropathy（SFN） is also known as painful small fiber neuropathy. It is difficult to diagnose this disease early due to the complex etiology and unclear pathogenesis. Paraesthesia and autonomic nerve dysfunction are the main clinical symptoms of SFN. The results of nerve conduction of routine electromyography are normal, SFN is often difficult to diagnose in early stage. SFN can be recurrent, with deteriorating neuralgia if it is not treated timely, and may even lead to sudden cardiac death. There are many diagnostic methods for SFN including clinical examination and assisted detections. Many assisting methods are used to diagnose the SFN, such as sympathetic skin response, skin biopsy, and current perception threshold, etc. Since there are no specific treatment methods, symptomatic treatment are mainly used, including opium analgesic, antidepressants, and physiotherapy, in addition to the etiological treatment.

关 键 词：小纤维神经病 临床表现 早期诊断 

分 类 号：R747.8[医药卫生—神经病学与精神病学]