miR-135a在消化系统肿瘤中的研究进展  

Progress of miR-135a in digestive system tumor

作　　者：荀静宇 李福军[1] 孙晨[1] 吴德全[1] 

机构地区：[1]哈尔滨医科大学附属第二医院普通外科六病房,黑龙江哈尔滨150086

出　　处：《胃肠病学和肝病学杂志》2017年第7期816-818,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：黑龙江省青年科学基金项目(QC2012C051)

摘　　要：microRNAs(miRNAs)是由17~27个核苷酸组成的非编码小RNA,它通过信使RNA(messenger RNA,mRNA)降解目标RNA或抑制蛋白质的翻译来调节基因的表达,大多数microRNAs都参与肿瘤细胞的增殖、扩散、转移和凋亡,并在肿瘤的发生、发展过程中扮演着重要角色。消化系统肿瘤的发生率和死亡率呈上升趋势,对人们的身体健康存在着严重威胁。相关研究表明miR-135a在肿瘤的早期诊断和相关治疗中都起到重要作用,本文将对miR-135a在消化系统肿瘤中的研究进展作一概述。MicroRNAs（miRNAs）is composed of 17-27 nucleotide non-coding small RNA,it regulates gene expression through the degradation of target RNA or inhibition of protein translation.Most of the microRNAs involved in the proliferation,spreading,metastasis and apoptosis of tumor cells,which play an important role in the occurrence and development of tumors.The incidence and mortality of digestive system cancer have been on an upward trend,it is a serious threat to people＇s health.Studies have shown that miR-135a plays an important role in early diagnosis and treatment of tumor,recently.This article will review the progress of miR-135a in digestive system tumor.

关 键 词：miR-135a 消化系统肿瘤 诊断 治疗 

分 类 号：R735[医药卫生—肿瘤]