M细胞及AIEC经M细胞途径致克罗恩病研究进展  

Research progress of M cell and AIEC caused Crohn's disease by M cell-mediated pathway

作　　者：杨厚涞 孙华文[1] 孙科明 王秋爽[1] 

机构地区：[1]武汉大学人民医院胃肠外科,湖北武汉430060

出　　处：《胃肠病学和肝病学杂志》2017年第7期819-822,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科技基金资助项目(81170368)

摘　　要：M细胞具有特殊的形态结构,其作为肠道一种免疫细胞,也是一种特殊的抗原转运细胞,与肠黏膜免疫功能密切相关。在克罗恩病(Crohn’s disease,CD)早期,存在M细胞增生、破裂这种细胞学水平的病理损伤,本研究就目前国内外学者所做M细胞的起源、形态结构、功能及贴壁侵入性大肠杆菌(adherent-invasive Escherchia coli,AIEC)经M细胞途径致CD研究进展作一概述。M cells,with special morphological structure,are a kind of immune cells in the gut,and also a kind of special antigen-transporting cells,and are closely related to the intestinal mucosal immune function.At an early stage of Crohn＇s disease（CD）,the presence of M cells proliferation and pathological fracture damage of cytology existed.This article will review literatures about M-cell origin,morphological structure,functions,and adherent-invasive Escherchia coli（AIEC）caused CD by M cell-mediated pathway in recent years.

关 键 词：M细胞 起源 形态结构 功能 克罗恩病 侵入性大肠杆菌 

分 类 号：R574.62[医药卫生—消化系统]