乏氧诱导的肿瘤生物学行为改变及乏氧示踪剂的应用进展  

Hypoxia-induced tumor biological behavior changes and application of radiotracers for PET imaging of tumor hypoxia

作　　者：张茗昱[1] 姜昊[1] 徐海龙[1] 姜慧杰[1] 

机构地区：[1]哈尔滨医科大学附属第二医院CT诊断科,150086

出　　处：《中华全科医师杂志》2017年第7期565-568,共4页Chinese Journal of General Practitioners

基　　金：国家“十二五”科技支撑计划课题（2015BA101809）;国家自然科学基金面上项目（81471736,81671760）;黑龙江省留学基金（LC2013C38）

摘　　要：乏氧存在于大多数实体肿瘤内部.乏氧状态下诱导生成的乏氧核心调控因子（HIF）可以通过增强肿瘤的侵袭性、促进肿瘤新生血管生成、破坏基因组的稳定性及改变肿瘤微环境来参与肿瘤发展的各个环节,并且为肿瘤转移、复发提供条件.肿瘤乏氧正电子发射型计算机断层显像成像是一种可以评估并且量化肿瘤乏氧微环境的重要非侵入性检查方法,深入研究乏氧PET示踪剂有助于临床在分子水平早期检测肿瘤乏氧及监测治疗疗效.Hypoxia exists in a wide range of advanced solid tumors and is often associated with poor prognosis.Hypoxia can enhance tumor invasion, promote tumor angiogenesis, impact genomic stability and change the tumor microenvironment by activating expression of relevant genes through hypoxia-induced factors （HIFs）.Hypoxia provides favorable conditions for tumor metastasis and relapse, and it is involved in all aspects of tumor development.The study of hypoxia in tumors may provide useful information for pre-clinical evaluation, individualized treatment and clinical prognosis.Positron emission tomography （PET） is a non-invasive imaging method, which can be used for assessing and quantifying tumor hypoxic microenvironment.This article reviews the mechanisms of hypoxia-induced tumor biological behavior changes and the research progress of the application of radiotracers for PET imaging of tumor hypoxia.

关 键 词：细胞低氧 肿瘤 缺氧诱导因子1 Α亚基 放射性示踪剂 

分 类 号：R730.4[医药卫生—肿瘤]