缺锌对大鼠学习记忆功能的影响  

Effects of zinc deficiency on learning and memory functions in rats

作　　者：张双庆[1] 张海波[2] 朱娅敏[2] 张彦[2] 

机构地区：[1]中国疾病预防控制中心营养与健康所,北京100050 [2]安琪酵母股份有限公司湖北省酵母功能重点实验室,宜昌443003

出　　处：《中国抗生素杂志》2017年第7期616-620,共5页Chinese Journal of Antibiotics

摘　　要：目的建立缺锌大鼠模型,并考察缺锌对大鼠学习记忆功能的影响。方法 5周龄大鼠喂养低锌饲料145d,考察缺锌大鼠表征、体重、血锌含量、Morris水迷宫实验和组织形态学变化,并与正常饲料喂养大鼠相比。结果与正常对照大鼠相比,缺锌大鼠体重增长显著缓慢,血锌含量显著低,平台驻留时间和穿梭平台象限次数明显减少。结论缺锌可引起大鼠学习记忆功能损害。Objective To establish a zinc deficiency rat model, and investigate effects of the zinc deficiency on learning and memory functions in rats. Methods Five-week rats were fed with low zinc diets for 145 days, and their appearance, body weight, plasma zinc, behaviors in the morris water maze test and histomorphological observations were compared to normal rats. Results Compared to normal rats, body weight gain, plasma zinc level, resident time and step-through time of zinc deficiency rats were significantly lower. Conclusion Zinc deficiency impaired functions of learning and memory in rats.

关 键 词：缺锌 学习 记忆 

分 类 号：R96[医药卫生—药理学] R151[医药卫生—药学]