依达拉奉对局灶性脑缺血大鼠脑梗死体积的影响  

Effect of Edaravone for Cerebral Infarction Volume of Rat with Focal Cerebral Ischemia

作　　者：罗凡[1] 林占东 郭瑞芳[1] 李雪[1] 陈婷[1] 

机构地区：[1]承德医学院附属医院老年病科,河北承德067000

出　　处：《世界最新医学信息文摘》2017年第15期1-2,共2页World Latest Medicine Information Electronic Version

摘　　要：目的探讨依达拉奉对脑缺血大鼠脑梗死体积的影响。方法 45只SD大鼠随机分为假手术组、缺血组和依达拉奉组,每组15只。采用大脑中动脉闭塞法(MCao)制备脑缺血模型,依达拉奉组从造模完成后3h按10mg/(kg·d)腹腔注射依达拉奉,连续给药3天。比较各组神经功能缺损评分,he染色观察脑组织形态学变化,2,3,5-三苯基氯化四氮唑(TTC)染色检测脑梗死体积。结果与缺血组比较,依达拉奉组神经缺损评分下降,脑梗死体积减小(均P<0.01)结论依达拉奉可缩小脑缺血大鼠脑梗死体积,从而减轻脑组织损伤。Objective to investigate effect of edaravone for cerebral infarction volume of rat with focal cerebral ischemia. Methods divide 45 SD rats randomly into sham operation group, ischemla group and edaravone group, 15 rats in each. With middle cerebral artery occlusion （MCAO） method, prepare cerebral ischemia model, inject 10mg/（kg.D） edaravone intraperitoneally for edaravone group 3h after modeling for continuous 3 days. Compare neural function defect scores of each group, and observe cerebral morphological changes with HE staining, detect cerebral infarction volume with 2,3,5-1riphenyl tetrazolium chloride（TIC） staining. Results compared with ischemia group, neural defect scores ofedaravone group decreased, and infarct volume decreased （P 〈 0.01） Conclusion edaravone can reduce cerebral infarction volume of rats with cerebral ischemia, so as to relieve injury of brain tissue.

关 键 词：脑缺血 依达拉奉 脑梗死 

分 类 号：R743.31[医药卫生—神经病学与精神病学]