miR-489在肿瘤中作用的研究进展  

Research progress in the action mechanism of miR-489 in tumors

作　　者：孙丹[1] 于萌[2] 黄志弘 朱育焱[1] 

机构地区：[1]中国医科大学附属第一医院泌尿外科,沈阳110001 [2]中国医科大学实验动物部,沈阳110001

出　　处：《生命的化学》2017年第3期329-335,共7页Chemistry of Life

基　　金：国家自然科学基金项目(81272834;81472404;81472403)

摘　　要：mi RNA是一类长度约为22 nt的内源性小分子非编码RNA,几乎参与了机体生命活动的所有过程。近年来研究发现,多种肿瘤组织中mi R-489表达下调,其通过转录后抑制靶基因,如HER2、AKT3、SPIN1等的表达,参与肿瘤细胞的增殖、凋亡、侵袭和转移等多种病理过程,并与肿瘤的耐药及发生、发展密切相关。因此,了解mi R-489的表达、调控及其在肿瘤等疾病中的作用及机制,可为其进一步的临床应用奠定基础。本文就mi R-489与恶性肿瘤关系的研究进展进行综述。Micro RNAs（mi RNAs） are a class of endogenous small regulatory non-coding RNAs with length of about 22 nt,which have been implicated in almost all the life processes.Recent studies have showed that the downregulation of mi RNA-489（mi R-489） expression could be detected in different kinds of tumors,and mi R-489 is involved in proliferation,apoptosis,invasion and metastasis of various tumor cells by directly suppressing the expressions of its target genes such as HER2,AKT3 and SPIN1.The dysregulated expression of mi R-489 is closely correlated with chemo-resistance and tumor development.Therefore,understanding the expression and regulation of mi R-489 and its role in tumor and other diseases will offer the foundation for further clinical application.This paper reviews the research progress of mi R-489 in malignant tumors.

关 键 词：MIRNA 肿瘤 靶基因表达调控 miR-489 

分 类 号：R730.2[医药卫生—肿瘤]