ICG清除试验与Child-Pugh分级、MELD评分相关性分析  

Correlation analysis of Indocyanine green clearance test with Child-Pugh classification and MELD score

作　　者：王君宜 杨丽莎[1] 

机构地区：[1]桂林医学院附属医院消化内科,广西桂林541001

出　　处：《华夏医学》2017年第3期111-114,共4页Acta Medicinae Sinica

基　　金：国家自然科学基金项目资助(81260602)

摘　　要：目的:探讨吲哚菁绿(ICG)清除试验与终末期肝病模型(MELD评分)的相关性。方法:收集252例肝癌患者的临床检测结果,包括常规肝肾功能结果、ICG清除试验结果,根据Child-Pugh评分分级,计算MELD评分。结果:Child-Pugh分级和MELD评分有显著相关性(P<0.05);吲哚菁绿15 min留置率(ICGR-15)、吲哚菁绿血浆清除率(k值)与MELD评分有显著相关性(P<0.05),ICGR-15与MELD评分呈正相关(r=0.591),k值与MELD评分呈负相关(r=-0.517)。结论:ICGR-15、Child-Pugh分级和MELD评分可以准确预测肝癌患者术前肝功能损伤的程度,三者同时使用可以获得相对精确的结果。Objective： To explore the correlation between Indocyanine green（ICG） clearance test and model for end-stage liver disease（MELD） score. Methods： The clinical results of 252 patients with hepatocellular carcinoma were collected,including routine liver and kidney function results and ICG clearance test results. The MELD score was calculated according to the Child-Pugh score. Results： ChildPugh grade and MELD score were significantly correlated（P〈0.05）,Indocyanine green retention rate at15 min（ICGR-15） and k value were significantly correlated with MELD score,while ICGR-15 and MELD score was positively correlated（r = 0.591）,but k value was negatively correlated with MELD score（r =-0.517）. Conclusion： It could accurately predict the degree of preoperative liver injury in HCC and get a relatively accurate result when ICGR-15,Child-Pugh classification and MELD score were used at the same time.

关 键 词：肝功能储备 吲哚菁绿15min留置率 MELD评分 

分 类 号：R735.7[医药卫生—肿瘤]