Polyethylene glycol phospholipids encapsulated silicon 2,3-naphthalocyanine dihydroxide nanoparticles(SiNcOH-DSPE-PEG(NH2)NPs) for single NIR laser induced cancer combination therapy  

作　　者：Jing-Ping Wei Xiao-Lan Chen Xiao-Yong Wang Jing-Chao Li Sai-Ge Shi Gang Liu Nan-Feng Zheng 

机构地区：[1]State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China [2]State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine, School of Public Health,Xiamen University, Xiamen 361005, China

出　　处：《Chinese Chemical Letters》2017年第6期1290-1299,共10页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21101131);National Basic Research Foundation(973)of China(No.2014CB932004);Natural Science Foundation of Fujian Province(No.2016J01073)

摘　　要：Currently,the combination of photothermal therapy（PTT） and photodynamic therapy（PDT） has emerged as a powerful technique for cancer treatment.However,most examples of combined PTT and PDT reported use multi-component nanocomposites under excitation of separate wavelength,resulting in complex treatment process.In this work,a novel theranostic nanoplatform（SiNcOH-DSPE-PEG（NH2）NPs） has been successfully developed by coating silicon 2,3-naphthalocyanine dihydroxide（SiNcOH）with DSPE-PEG and DSPE-PEG-NH2 for photoacoustic（PA） imaging-guided PTT and PDT tumor ablation for the first time.The as-prepared single-agent SiNcOH-DSPE-PEG（NH2） NPs not only have good water solubility and biocompatibility,but also exhibit high photothermal conversion efficiency and singlet oxygen generation capability upon 808 nm NIR laser irradiation.In addition,owing to their high absorption at NIR region,the SiNcOH-DSPE-PEG（NH2） NPs can also be employed as an effective diagnostic nanoagent for photoacoustic（PA） imaging.In vitro and in vivo experimental results clearly indicated that the simultaneously combined PTT and PDT under the guidance of PA imaging with single NIR laser excitation can effectively kill cancer cells or eradicate tumor tissues.Taking facile synthesis and high efficiency in cancer treatment by SiNcOH-DSPE-PEG（NH2） NPs into consideration,our study provides a promising strategy to realize molecular imaging-guided combination therapy.Currently,the combination of photothermal therapy（PTT） and photodynamic therapy（PDT） has emerged as a powerful technique for cancer treatment.However,most examples of combined PTT and PDT reported use multi-component nanocomposites under excitation of separate wavelength,resulting in complex treatment process.In this work,a novel theranostic nanoplatform（SiNcOH-DSPE-PEG（NH2）NPs） has been successfully developed by coating silicon 2,3-naphthalocyanine dihydroxide（SiNcOH）with DSPE-PEG and DSPE-PEG-NH2 for photoacoustic（PA） imaging-guided PTT and PDT tumor ablation for the first time.The as-prepared single-agent SiNcOH-DSPE-PEG（NH2） NPs not only have good water solubility and biocompatibility,but also exhibit high photothermal conversion efficiency and singlet oxygen generation capability upon 808 nm NIR laser irradiation.In addition,owing to their high absorption at NIR region,the SiNcOH-DSPE-PEG（NH2） NPs can also be employed as an effective diagnostic nanoagent for photoacoustic（PA） imaging.In vitro and in vivo experimental results clearly indicated that the simultaneously combined PTT and PDT under the guidance of PA imaging with single NIR laser excitation can effectively kill cancer cells or eradicate tumor tissues.Taking facile synthesis and high efficiency in cancer treatment by SiNcOH-DSPE-PEG（NH2） NPs into consideration,our study provides a promising strategy to realize molecular imaging-guided combination therapy.

关 键 词：SiNcOH-DSPE-PEG（NH2） NPs Photothermal therapy（PTT） Photodynamic therapy（PDT） Photoacoustic（PA） imaging Combinatorial PTT/PDT 

分 类 号：R730.5[医药卫生—肿瘤] TQ460.1[医药卫生—临床医学]