^(18)F-FDG PET/CT在心脏肿瘤诊断的临床应用价值  

Clinical Application of ^(18)F-FDG PET/CT in Diagnosis of Cardiac Neoplasm

作　　者：卢霞[1] 孟晶晶[1] 柏江[1] 王蒨[1] 张晓丽[1] 王荣福[2] 

机构地区：[1]首都医科大学附属北京安贞医院,北京100029 [2]北京大学第一医院,北京100034

出　　处：《肿瘤学杂志》2017年第6期474-478,共5页Journal of Chinese Oncology

基　　金：国家自然科学基金(81641072);北京市医院管理局"青苗"计划(QML20150605);北京市优秀人才(2015000021469G197)

摘　　要：[目的]评价^(18)F-FDG PET/CT在心脏肿瘤诊断中的临床应用价值。[方法]回顾性分析自2014年10月至2017年3月在首都医科大学附属北京安贞医院行^(18)F-FDG PET/CT全身显像的心脏肿瘤患者共27例,患者最终诊断以手术病理结果或随访结果为依据。^(18)F-FDG PET/CT影像心脏占位病变可见明显异常FDG浓聚灶,SUV_(max)≥5.7判断为恶性病变可能大,并与最终诊断结果进行比较,分析^(18)F-FDG PET/CT在心脏占位性病变良恶性的鉴别能力。采用两样本t检验分析数据。[结果]27例心脏肿瘤患者中,恶性11例,良性占位16例。^(18)FFDG PET/CT显像,恶性占位(n=11)平均SUV_(max)9.03±4.5(2.0~15.9)明显高于良性心脏占位性病变(n=16)平均SUV_(max)3.25±2.51(0.6~10.2),差异有统计学意义(t=4.25,P<0.001)。将SUV≥5.7作为恶性诊断的阈值,^(18)F-FDG PET/CT诊断心脏恶性肿瘤的灵敏度81.8%(9/11),特异性93.8%(15/16),准确率88.9%(24/27)。[结论]全身^(18)F-FDG PET/CT检查对心脏肿瘤,特别是原发性心脏肿瘤良恶性诊断有重要的临床价值。[Objective] To evaluate the clinical value of ^18F-FDG PET/CT in the diagnosis of cardiac neoplasm. [Methods] From October 2014 to March 2017,a total of 27 patients diagnosed with cardiac neoplasm underwent whole body ^18F-FDG PET/CT imaging were respectively analysised. ^18F-FDG PET/CT diagnosis was confirmed by either histopathology or the follow-up outcome. Cardiac space-occupying lesions shows increased FDG uptake in the imaging of PET/CT and diagnosed malignance lesions when SUVmax≥5.7. Then compared with histopathology or the follow-up outcome to evaluate the clinical application of ^18F-FDG PET/CT imaging in the diagnosis of cardiac neoplasm. Two-sample t test was used for data analysis. [Results] Among 27 cases of cardiac space-occupying lesions,11 cases were malignant tumors,16 cases were benign tumors.The average SUVmaxof malignant tumors（n=11） was 9.03±4.5,which was significantly higher than that of benign tumors（n=16,3.25±2.51）（t=4.25,P0.001）. With a cut-off SUVmax≥ 5.7, ^18F-FDG PET/CT could be used to diagnose cardiac neoplasm with a sensitivity of 81.8%（9/11）,specificity of 93.8%（15/16）,and accuracy of 88.9%（24/27）. [Conclusion] The whole body scan of18 FFDG PET/CT can aid the noninvasive diagnosis of cardiac malignant tumors from benign lesions.

关 键 词：心脏肿瘤 ^18F-FDG PET/CT 鉴别诊断 

分 类 号：R732.1[医药卫生—肿瘤]