分子影像技术在肿瘤细胞凋亡的研究现状及进展  

Current Status and Advances on the Application of Molecular Imaging Techniques in Cancer Cell Apoptosis

作　　者：刘岩[1] 任佳忠 杨国仁[2] 

机构地区：[1]济南大学,山东省医学科学院医学与生命科学学院,山东济南250117 [2]山东大学附属山东省肿瘤医院,山东济南250117

出　　处：《肿瘤学杂志》2017年第6期496-501,共6页Journal of Chinese Oncology

摘　　要：细胞凋亡是由多种基因调控的主动性细胞死亡过程。通过放疗、化疗等手段诱导肿瘤细胞凋亡是各种抗肿瘤治疗的主要机制之一。分子影像学可以在细胞和分子水平上对活体内细胞凋亡的生物过程和某些疾病的发生机制进行定性、定量、实时监测。分子影像学技术主要包括PET、SPECT、MRI、超声成像、光学成像。全文主要对分子影像技术在肿瘤细胞凋亡的应用进行综述。Apoptosis is a programmed cell death process involving a variety of gene regulation. To induce tumor cell apoptosis is one of the main mechanisms of antitumor therapy,including radiotherapy and chemotherapy. Cell apoptosis and biological process of diseases can be real-time,qualitatively and quantitatively monitored at the cellular and molecular level in the living body.The molecular imaging techniques include PET,SPECT,MRI,ultrasonic imaging and optical imaging. This article reviews the value of various molecular imaging techniques in monitoring of cancer cell apoptosis.

关 键 词：肿瘤细胞 细胞凋亡 分子影像探针 

分 类 号：R73[医药卫生—肿瘤]