胃癌发生及其耐药性形成中的相关信号通路  

The signaling pathways in the formation of gastric cancer and its drug resistance

作　　者：应镇光 张焕芝[2] 靳广毅[1] 王亮[2] 沙鸥[2] 

机构地区：[1]深圳大学医学院药学系,深圳51800 [2]深圳大学医学院医学系,深圳51800

出　　处：《中国组织化学与细胞化学杂志》2016年第3期291-294,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：深圳市科技攻关项目(课题号:JSGG20150512162446307);深圳市科技计划项目(JCYJ20150525092940973);深圳大学医学教学实验中心学生创新发展基金基础实验项目(课题号:2015551);深圳大学教学改革研究项目(项目编号:JG2012053)

摘　　要：胃癌是常见的消化道恶性肿瘤,而化疗药物的耐药性严重影响晚期胃癌患者的化疗效果。本文总结了多种与胃癌的发生及耐药性产生相关的信号通路,包括rnTOR、Nrf2-ARE、Notch、Hedgehog和Wnt。这些信号通路不仅决定着胃癌等恶性肿瘤的发生、分化与转移,更影响着恶性肿瘤耐药性的产生,而耐药性正是目前肿瘤化疗的最大障碍。研究这些信号通路可以从分子水平研究癌症发生的机理从而阻断肿瘤的生长,从这些肿瘤相关信号通路中亦能了解到肿瘤耐药性产生的机制,为胃癌等恶性肿瘤研究和治疗提供新的思路。Gastric cancer is a common malignant tumor of the digestive system.Drug resistance reduces the chemotherapeutic effect on the patients with advanced gastric cancer.This paper reviewed the recent research progress in a variety of signaling pathways during the formation of gastric cancer and its drug resistance,including mTOR,Nrf2- ARE,Notch,Hedgehog and Wnt.These pathways not only determine the occurrence,differentiation and metastasis of cancers,but also affect the formation of drug resistance.The latter is the biggest obstacle to cancer chemotherapy.The studies on these pathways may help researchers to understand the mechanism of cancer formation so as to block the growth of cancers at the molecular level.In addition,these studies are helpful for finding out the mechanism underlying drug resistance and providing researcher with new clues for the research and gastric cancer.

关 键 词：胃癌 mTOR Nrf2-ARE NOTCH WNT HEDGEHOG 耐药性 信号通路 

分 类 号：R735.2[医药卫生—肿瘤]