胃微生态与胃癌的研究进展  

Research progress of gastric microecology and gastric cancer

作　　者：韩渭丽[1] 曹莹[1] 钱美睿[1] 聂勇战[2] HAN Wei-li CAO Ying QIAN Mei-rui NIE Yong-zhan(State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi＂ an 710043, China)

机构地区：[1]第四军医大学西京消化病医院肿瘤生物学国家重点实验室,西安710043 [2]第四军医大学西京消化病医院消化内科,西安710043

出　　处：《传染病信息》2017年第3期144-147,共4页Infectious Disease Information

基　　金：重大慢性非传染性疾病防控研究(2016YFC1303204);国家科技部支撑项目(2015BAI13B00)

摘　　要：胃微生态平衡是人体健康的重要前提,幽门螺杆菌(Helicobacter pylori,Hp)是目前已发现的与胃癌相关的关键病原体之一,普遍存在于人胃黏膜上皮。Hp感染可引起胃内其他菌群的改变,还可引起长期慢性的胃黏膜损伤,导致一系列胃黏膜上皮恶性进展和胃癌的发生。本文就胃微生态与Hp感染的关系、Hp感染在胃癌发生中的作用、胃内其他菌群在胃癌发生中的作用及微生态制剂在胃癌治疗的作用进行综述。进一步揭示Hp感染对胃微生态平衡的影响,胃微生态平衡和Hp感染在胃癌发生发展中的作用及微生态制剂在胃癌治疗中的意义。Gastric microecology is the critical premise of human health. Helicobacter pylori （Hp） is one of the pivotal pathogens related to gastric cancer, and Hp is commonly present in human gastric epithelial cells. Hp infection can give rise to changes of other bacterial flora in the stomach and long-term chronic gastric mucosal injuries, thus lead to a series of malignant progression of gastric mucosa, and even gastric cancer. In this review, we summarize the relationship of gastric microecology and Hp infection, the role of Hp infection and other gastric flora in gastric carcinogenesis, and the effect of microecologics in gastric cancer treatment. This review aims to further reveal the influence of Hp infection in gastric microecology, the role of gastric microecology and Hp infection in gastric carcinogenesis, and the significance of microecologics in the treatment of gastric cancer.

关 键 词：胃微生态 幽门螺杆菌 胃癌 毒力因子 微生态制剂 

分 类 号：R735.2[医药卫生—肿瘤] R37[医药卫生—临床医学]