精神分裂症患者及一级家属前额叶血流非对称性的近红外光谱成像研究  

A comparative study of near infrared spectroscopy for prefrontal cortex flow asymmetry in patients with schizophrenia and their first degree relatives

作　　者：杨和增[1] 万凤[1] 赖文涛[1] 李敏智[1] 陈周文 

机构地区：[1]深圳市康宁医院,深圳市心理健康实验室,深圳市精神卫生中心,广东深圳518020

出　　处：《精神医学杂志》2017年第2期88-92,共5页Journal of Psychiatry

基　　金：2015年度广东省医学科学技术研究基金项目(编号:A2015361)

摘　　要：目的探讨精神分裂症患者及未患病一级家属前额叶血流非对称性的近红外光谱成像特征。方法选取精神分裂症患者(患者组)21例、未患病一级家属(家属组)20例、健康对照(健康组)20例,行近红外光谱成像检查,对三组对象前额叶左右对称位置的通道进行比较,分析对称性。结果健康组的通道C6与通道C16组合(C6-C16)氧合血红蛋白信号左右对比具有统计学意义(P<0.05),而在患者组与家属组中的则无统计学意义(P>0.05)。对照组的通道组合C3-C20、C4-C19、C11-C13脱氧血红蛋白信号左右对比具有统计学意义(P<0.05),而在患者组与家属组中则无统计学意义(P>0.05)。患者组C2-C17的脱氧血红蛋白信号具有左右非对称性(P<0.05)。结论精神分裂症患者组及其一级家属的前额叶存在血流非对称性。Objective To investigate near infrared spectroscopy for prefrontal cortex flow asymmetry in patients with schizophrenia and their first degree relatives. Methods A total of 21 patients with schizophrenia in SZ group,20 first degree relatives of the patients without mental disorders in FR group and 21 healthy people in HY group were selected and examined with near infrared spectroscopy for prefrontal cortex flow asymmetry. Results There was significant difference for the asymmetry of oxyhemoglobin between Channel 6 and Channel 16 in HY group（ P〈0. 05）,but there were no differences in SZ group and FR group（ P〈0. 05）. There were significant differences for the asymmetry of deoxygenated hemoglobin between Channel 3 and Channel 20,Channel 4 and Channel 19,Channel 11 and Channel 13 in HY group（ P〈0. 05）,but there were no differences in SZ group and FR group（ P〈0. 05）. There was significant difference for the asymmetry of deoxygenated hemoglobin between Channel 2 and Channel 17 in SZ group（ P〈0. 05）. Conclusion There is prefrontal cortex flow asymmetry in patients with schizophrenia and their first degree relatives.

关 键 词：近红外光谱成像 精神分裂症 非对称性 一级亲属 

分 类 号：R749.3[医药卫生—神经病学与精神病学]