涎腺腺样囊性癌中HIF-1α和BCL-2的表达及意义  

Expression of HIF-1α and BCL-2 in salivary adenoid cystic carcinoma and its clinical significance

作　　者：鲍合刚 肖亮[1] 孟刚[2] 王岳君[3] 王芬[1] 金问森[1] 

机构地区：[1]安徽医科大学核医学教研室,合肥230032 [2]安徽医科大学第一附属医院病理科,合肥230022 [3]安徽医科大学第四附属医院病理科,合肥230001

出　　处：《临床与实验病理学杂志》2017年第7期728-732,共5页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学基金(U1432124)

摘　　要：目的分析涎腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)中HIF-1α和BCL-2的表达水平,探讨两者之间表达的相关性及与临床病理特征的关系。方法采用免疫组化SP法检测56例SACC中HIF-1α和BCL-2的表达,并分析两者的相关性。结果 SACC中HIF-1α的阳性率为64.3%,其表达水平与肿瘤TNM分期及来源腺体呈明显相关(P<0.05)。SACC中BCL-2的阳性率为98.2%,其表达水平与HIF-1α呈正相关(P<0.05),且HIF-1α与肿瘤TNM分期之间的相关性依赖于BCL-2的强表达(P<0.05)。结论高表达的HIF-1α和BCL-2可能影响SACC的分期。ABSTRACT Purpose To investigate the relationship of HIF-1α, BCL-2 and clinicopathological features in salivary ade-noid cystic carcinoma by detecting the levels of two proteins Methods Immunohistochemical of SP staining assay was used to detect the level of HIF-Iot and BCL-2 expression in fifty-six section from primary resection of salivary adenoid cystic carcino- ma. Furthermore, the correlation between the expressions of two proteins with clinical data was evaluated through differently sta- tistical analysis. Results Thirty-six samples （64.3%） were found to express HIF-1α. The level of HIF-1α was significantly correlated with TNM stage of tumors and the primary site of sali- vary adenoid cystic carcinoma （P 〈 0. 05 ）. Positive BCL-2 ex- pression was detected in fifty-five cases （98.2%）. The level of HIF-1α was positively correlated with that of BCL-2 （P 〈 0. 05 ） and the significant correlation between HIF-1α and TNM stage was dependent upon the strong expression of BCL-2 （ P 〈0. 05 ）. Conclusion It is therefore indicated that the expression of HIF- let and BCL-2 may influence the clinical stage of salivary ade- noid cystic carcinoma.

关 键 词：涎腺肿瘤 腺样囊性癌 HIF-1Α BCL-2 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]