榄香烯与卡培他滨联合多西他赛治疗有心脏高危因素乳腺癌的临床观察  

The Clinical Observed of Elemene and Capecitabine Combined with Docetaxel in the Treatment of Breast Cancer with Cardiac Risk Factors

作　　者：董岩[1] 宫文欢 付虹[1] 巩鹏[1] 张斌[1] 丛滔 徐英辉[1] 邹丽娟[1] 殷朔[1] 高亚杰[1] DONG Yan GONG Wen-huan FU Hong et al(Department of Oncology , the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China)

机构地区：[1]大连医科大学附属第一医院肿瘤科,辽宁大连116011

出　　处：《医学与哲学（B）》2017年第6期31-34,54,共5页Medicine & Philosophy(B)

基　　金：2011年辽宁省科技厅项目(201102050)

摘　　要：为了观察榄香烯联合多西他赛和卡培他滨联合多西他赛治疗有心脏高危因素乳腺癌的近期疗效和安全性。选取60例具有心脏高危因素的晚期乳腺癌患者,随机分为ET组(榄香烯联合多西他赛)32例和XT组(卡培他滨联合多西他赛)28例。两组患者计划完成4个~6个周期化疗,每2个周期评价疗效。ET组和XT组疾病控制率差异无统计学意义(65.63%vs.67.86%,P>0.05),两组中位肿瘤进展时间差异无统计学意义(6.65个月vs.6.90个月,P>0.05)。ET组的心脏应变性恶化程度较XT组显著减轻(P<0.05),而两组在血液毒性、肝肾功能和外周神经毒性无明显差异,但是恶心、呕吐、腹泻等消化道反应XT组明显多于ET组。榄香烯联合多西他赛和卡培他滨联合多西他赛均是治疗有心脏高危因素乳腺癌有效方案,但榄香烯联合多西他赛方案消化道毒性较轻,并在心功能保护方面优于卡培他滨联合多西他赛方案。In order to observe the current curative effect and security of elemene combined with docetaxel and capecitabine combined with docetaxel used in breast cancer with cardiac risk factors.60 patients with cardiac risk factors of advanced breast cancer were selected,randomly dividing into ET group（elemene combined with docetaxel）32cases and XT group（capecitabine combined with docetaxel）28cases.4-6cycles of chemotherapy were scheduled for two groups of patients,evaluating the curative efficacy every 2cycles.Disease control rate of group ET and group XT has no statistically significant difference（65.63% vs.67.86%,P〉0.05）,Median time to tumor progression of two groups has no statistically significant difference（6.65 months vs.6.90 months,P〉0.05）.The deterioration＇s degree of cardiac degeneration was significantly superior to group XT（P〈0.05）,there was no significant difference between the two groups in hematological toxicity,hepatorenal function and peripheral neurotoxicity.But group XT is obviously more than group ET in gastrointestinal reaction such as nausea,vomit and diarrhea.Both elemene combined with docetaxel and capecitabine combined with docetaxel are the effective treatment in breast cancer with cardiac risk factors,however the ET plan is more slight in gastrointestinal reaction,and the protection of heart which is better than XT plan.

关 键 词：榄香烯 卡培他滨 多西他赛 乳腺癌 心脏毒性 

分 类 号：R737.9[医药卫生—肿瘤]