早期宫颈腺癌术后同步放化疗的预后不良因素分析  

Analysis of Chemoradiotherapy Curative Adverse Prognostic Factors for Early Postoperative Cervical Adenocarcinoma

作　　者：张锋[1] 张卓[1] 邹丽娟[1] ZHANG Feng ZHANG Zhuo ZOU Li-juan(Department of Oncology, the 2nd Affiliated Hospital of Dalian Medical University, Dalian 116023, China)

机构地区：[1]大连医科大学附属第二医院肿瘤放疗科,辽宁大连116023

出　　处：《医学与哲学（B）》2017年第4期50-54,共5页Medicine & Philosophy(B)

摘　　要：分析影响早期宫颈腺癌术后同步放化疗的预后不良因素,以期为宫颈腺癌术后临床治疗方法的选择提供理论依据。回顾性分析2003年1月~2009年1月在大连医科大学附属第二医院诊治的35例ⅠB2~ⅡA期宫颈腺癌术后患者,18例采用单纯盆腔外照射,17例采用盆腔外照射+腔内照射,放射治疗期间同步顺铂增敏。复发/转移率单因素分析结果示:盆腔外照射+腔内照射复发率降低(P<0.05);间质浸润深度、淋巴结累及阳性和脉管癌栓与转移密切相关,P值分别为0.023、0.000和0.001。多因素分析结果显示间质浸润深度、淋巴结累及阳性和脉管癌栓均为转移的独立预后影响因素(P<0.05)。总生存率相关性因素分析结果示:间质浸润深度、淋巴结累及和脉管癌栓为其独立预后影响因素(P<0.05)。无病生存率相关因素分析结果示:间质浸润深度、淋巴结累及和脉管癌栓为其独立预后影响因素(P<0.05)。The purpose of this study was to analysis the prognostic factors , which could provide the theoretical basis for clinical treatment of cervical adenocarcinoma after operation. The 35 patients of International Federation of Gynecology and Obstetrics （FIGO） stages Ⅰ B- Ⅱ A were enrolled in the study from January 2005 to January 2012 at the second hospital of Dalian medical university. There are 18 patients underwent external radio therapy for whole pelvic radiotherapy. 17 patients underwent external radio therapy and vaginal brachytherapy. During radiotherapy, cisplatin increased sensitivity, and the DP regimen was used in the treatment of 4-6. Cervical adenocarcinoma metastasis and recurrence of single factor analysis showed： depth of stromal invasion is more than 1/2 muscle layer, lymph node metastasis and lymphovascular space invasion are closely related with metastasis and recurrence, P values were 0. 023, 0. 000 and 0. 001. The results of multivariate analysis showed that lymphovascular space invasion is independent prognostic factor of recurrence and metastasis （P〈0.05）. The 5-year overall survival rate of single factor analysis showed： lymphovascular space invasion is the most significant factor which affects the survival rate （P〈0. 05）. The 5-year overall survival rate of single factor analysis showed： depth of stromal invasion and lymphovascular space invasion are the significant factors which affect the survival rate （P〈0.05）. The results of multivariate analysis showed that lymphovascular space invasion is independent prognostic factor of disease-free survival rate （P〈0.05）.

关 键 词：同步放化疗 顺铂 早期宫颈腺癌术后 预后因素分析 

分 类 号：R737.33[医药卫生—肿瘤]