自噬在膀胱癌中相关机制和治疗的研究进展  

Research Progress of Autophagy in the Mechanism and Treatment of Bladder Cancer

作　　者：何俊[1] 王剑松[1] 刘靖宇[1] 王海峰 HE Jun WANG Jian-song LIU J ing-yu et al(Department of Urology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China)

机构地区：[1]昆明医科大学第二附属医院泌尿外科,云南昆明650101

出　　处：《医学与哲学（B）》2017年第4期67-70,共4页Medicine & Philosophy(B)

基　　金：2017年国家自然科学基金(81660422);2015年云南省科技厅面上项目(2015FB196);2014年云南省教育厅基金(2014Z072)

摘　　要：由于具有较高的复发率和进展风险,膀胱癌的发病率一直高居不下。尽管细胞凋亡长期以来是癌症进展的已建立的途径,但是包括自噬作用的非凋亡途径作用日益显著。作为正常的生理过程,自噬能在发育和营养应激期间稳定能量来源,并且对于包括癌症在内的各种疾病中所起到存活或杀伤细胞的双重作用十分必要。最近对自噬在其他恶性肿瘤中的作用的研究已引起对自噬在膀胱癌中的作用机制的极大兴趣。为此,笔者总结了文献中关于自噬在膀胱癌机制和治疗中的作用。The incidence of bladder cancer remains high due to high recurrence rates and risk of progression. While apoptosis deregulation has long been an established pathway for cancer progression, nonapoptotic pathways, including its role in autophagy,have gained prominently. As a normal physiological process, autophagy is essential to stabilize the source of energy during development and nutritional stress and plays the dual role of survival or cell killing in various diseases including cancer. Recent research in autophagy in other malignancies has led to greater interest in the role of autophagy in bladder cancer. In particular, we summarize the literatures regarding the research progress of autophagy in bladder cancer mechanism and autophagy-related therapy.

关 键 词：自噬 膀胱癌 自噬机制 自噬相关疗法 

分 类 号：R737.14[医药卫生—肿瘤]