治疗致盲性眼病的干细胞来源及应用  

Stem Cells in Treatment of Blinding Eye Disease: Origination and Application

作　　者：何翔宇[1] 龚宇[2] 卞白士姣 付琰[2] 阴正勤[1,2] He Xiangyu Gong Yu Bian Baishijiao Fu Yan Yin Zhengqin(Department of Ophthalmology, General Hospital of Chinese People＇s Liberation Army, Beijing 100853, China Southwest Eye Hospital, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)

机构地区：[1]中国人民解放军总医院眼科,北京100853 [2]第三军医大学西南眼科医院,重庆400038

出　　处：《中国细胞生物学学报》2017年第6期833-838,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81130017);国家重点基础研究发展计划(973计划)(批准号:2013cb967002)资助的课题~~

摘　　要：除了人胚胎、胎儿脐带血中已经发现的多种干细胞,在成体哺乳动物组织器官特异性的干细胞龛位(生态位)中,包括骨髓、脑、皮肤、心脏、眼、肾、肺、胃肠道、胰腺、肝、乳房、卵巢以及睾丸中也发现了相当种类的成体干细胞群。以上干细胞均处于相对未分化状态,并保留了自我更新及向特定组织分化的潜能,这让干细胞具备了维持组织稳态和修复创伤后组织的能力。近年来,再生医学领域不乏运用干细胞直接进行或诱导成为视觉相关细胞后再进行眼病治疗的研究,体现了干细胞治疗极其广阔的应用前景。该文将综述用于致盲性眼病治疗的干细胞潜在来源以及相关研究进展。Besides stem cells established from embryos, fetal tissues as well as umbilical cord blood, various stem cell linages have been identified in specific tissue niches throughout the adult mammalians body such as bone marrow, brain, skin, heart, eyes, kidney, lung, gastrointestinal tract, pancreas, liver, breast, ovary, and prostate. All stem cells are undifferentiated biological cells that can generate any germ-layer types of progenitor populations or terminal somatic cells and exhibit self-renewal through symmetric or asymmetric cell division. Thus, stem cells could potentially contribute to tissue homeostasis or to tissue regeneration by signaling factors paracrine or cells replenishing after lesions occur. In recent years, the remarkable progress made in regenerative medicine by using stem cell or stem cell induced cellula visualis indicates promise for the treatment of ocular diseases. This paper reviewed the research progress and potential source of stem cell for the treatment of blinding ocular diseases.

关 键 词：致盲性眼病 干细胞 成体干细胞 诱导多能干细胞 胚胎干细胞 视网膜祖细胞 

分 类 号：R77[医药卫生—眼科]