妊娠的β珠蛋白生成障碍性贫血女性红细胞参数的变化分析  

Changes of red blood cell parameters in pregnancy women with β-mediterranean anemia

作　　者：刘雄伟[1] 吴泽[1] 黄衍锋[1] 许瑞环[1] 陈建霞[1] 

机构地区：[1]广东省深圳市龙岗中心医院检验科,518116

出　　处：《国际检验医学杂志》2017年第14期1904-1906,共3页International Journal of Laboratory Medicine

基　　金：深圳市科技计划项目(JCYJ20140411150717058)

摘　　要：目的探讨妊娠β珠蛋白生成障碍性贫血(简称β地贫)女性红细胞参数的变化及鉴别诊断中的价值。方法选取2014年7月至2015年12月在该院进行围产期建卡的100例β地贫妊娠女性纳入β地贫妊娠组,正常妊娠女性100例纳入正常妊娠组,100例妊娠期缺铁性贫血女性纳入缺铁性贫血妊娠组,分别检测各组的平均红细胞体积(MCV)、平均红细胞血红蛋白(MCH)、网织红细胞百分率(Ret%),并进行比较。结果β地贫妊娠组的MCV、MCH低于正常妊娠组、缺铁性贫血妊娠组,Ret%高于正常妊娠组、缺铁性贫血妊娠组,差异均有统计学意义(P<0.05)。Ret%鉴别诊断β地贫妊娠和缺铁性贫血妊娠的最佳临界值为1.7%,灵敏度为63.00%,特异度为74.00%,受试者工作特征曲线下面积为0.841。MCV、MCH、Ret%联合检测鉴别诊断β地贫妊娠和缺铁性贫血妊娠的灵敏度为84.00%,特异度为90.00%。结论妊娠β地贫女性红细胞参数MCV、MCH、Ret%较正常妊娠及缺铁性贫血女性均有明显变化,MCV、MCH、Ret%3项指标联合检测的灵敏度和特异度更高,能够明显地提高鉴别诊断β地贫妊娠和缺铁性贫血妊娠的能力。Objective To investigate the changes of erythrocyte parameters and the value of differential diagnosis in pregnant women withβ-mediterranean anemia.Methods A total of 300 pregnancy women from July 2014 to December 2015 in Center Hospital of Longgang were recruited in this study,100 pregnant women withβ-mediterranean anemia inβ-mediterranean anemia pregnancy group,100 healthy pregnant women in normal pregnancy group,100 pregnant women with iron deficiency anemia in iron deficiency anemia pregnancy group.Mean red cell volume（MCV）,mean erythrocyte hemoglobin（MCH）,reticulocyte percentage（Ret%）were detected and compared in the three groups.Results Compared with the normal pregnancy group and iron deficiency anemia pregnancy group,the MCV,MCH significantly reduced,and Ret% significantly rised in theβ-mediterranean anemia pregnant group,the differences were significant（P〈0.05）.The best cut-off value of Ret% was 1.7%in differential diagnosis ofβ-mediterranean anemia pregnancy and iron deficiency anemia pregnancy,the sensitivity was 63.00%,the specificity was 74.00%,the area under of receiver operating characteristic curve was 0.841.The sensitivity of joint detection including MCV,MCH and Ret%in differential diagnosis ofβ-mediterranean anemia pregnancy and iron deficiency anemia pregnancy was 84.00%,the specificity was90.00%.Conclusion MCV,MCH and Ret%in pregnancy women withβ-mediterranean anemia changes significant compared with normal pregnancy group and iron deficiency anemia pregnancy group,the joint detection including MCV,MCH and Ret%could significantly improve the differential diagnosis ofβ-mediterranean anemia and iron deficiency anemia in pregnancy women.

关 键 词：妊娠 Β珠蛋白生成障碍性贫血 红细胞参数 

分 类 号：R446.1[医药卫生—诊断学] R714.254[医药卫生—临床医学]