巨噬细胞功能和炎症消退机制及与牙周炎关系研究进展  

Advances in macrophage function and its anti-inflammatory and proresolving activity and role in periodontitis development

作　　者：白林[1] 辛月娇 段丁瑜[1] 徐屹[1] 

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床研究中心,四川大学华西口腔医院牙周科,成都610041

出　　处：《华西口腔医学杂志》2017年第4期427-432,共6页West China Journal of Stomatology

基　　金：四川省科技厅科技支撑计划(2015SZ0137)~~

摘　　要：巨噬细胞是人体固有免疫系统中重要的组成部分,具有强大的识别、吞噬、清除细菌及外来异物的功能。牙周炎是一种以牙龈炎症和牙槽骨丧失为特征的慢性感染性疾病,是成年人失牙的主要病因。目前已经明确,牙周炎的组织破坏是由宿主对感染的免疫应答引起的,巨噬细胞作为宿主免疫应答的重要组成部分,在炎症的发生发展中起重要作用。近年研究显示,巨噬细胞在炎症消退过程中亦扮演着重要作用。本文就巨噬细胞在炎症的发生、发展及消退中的作用进行综述,并总结了其在牙周炎发展及治疗中可能的作用。Macrophage plays an important role in human innate immune system. It has powerful functions, such as recog- nition, phagocytosis, and bacteria and foreign body removal. Periodontitis, which is a chronic infectious disease characterized by gum inflammation and bone loss, is a major cause of tooth loss in adults. Several studies demonstrated that periodontal tissue destruction is caused by the host immune response defending against infections. As an important part of host immune response, macrophage is also involved in periodontitis pathogenesis. Recently, anti-inflammatory and proresolving activities of macrophage was discovered. Thus, the complex function of macrophage in the occurrence, development, and resolution of inflammation and its potential role in periodontitis were reviewed.

关 键 词：巨噬细胞 牙周炎 极化 胞葬 促炎消散介质 脂氧素 

分 类 号：R781.42[医药卫生—口腔医学]