阿司匹林联合氯吡格雷治疗缺血性脑卒中的疗效及对血小板聚集率的影响  

Curative effect of aspirin combined with plavix on ischemic stroke and its impact on platelet aggregation rate

作　　者：段发亮[1] 黄从刚[1] 倪厚杰[2] 闵强[1] 黄乔春[1] 吴京雷[1] 王远[1] 宋平[1] 

机构地区：[1]武汉市第一医院神经外科,430022 [2]武汉市第一医院神经内科,430022

出　　处：《中国临床神经外科杂志》2017年第7期470-472,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨阿司匹林联合氯吡格雷治疗缺血性脑卒中的疗效及其病人血小板聚集率的影响。方法回顾性分析2014年6月至2015年6月收治的292例缺血性脑卒中的临床资料。根据治疗方法分为常规组(146例)与联合组(146例),常规组给予阿司匹林(100 mg/d)治疗,联合组在常规组治疗的基础上给予氯吡格雷(75 mg/d)治疗。治疗前、治疗后2周,比较两组血小板聚集率和美国国立卫生研究所脑卒中量表(NIHSS)评分。结果治疗前,两组NIHSS评分和血小板聚集率均无明显差异(P>0.05);治疗后2周,两组NIHSS评分和血小板聚集率均明显改善(P<0.05),而且,联合组明显优于常规组(P<0.05)。结论阿司匹林与氯吡格雷可以发挥协同作用,进一步降低缺血性脑卒中病人血小板的聚集率,对缺血性脑卒中有更好的疗效。Objective To investigate the curative effect of aspirin combined with plavix on ischemic stroke and its impact on platelet aggregation rate. Methods The clinical data of 292 patients with ischemic stroke, of whom, 146 patients were treated by routine treatment and aspirin （100 mg, qd; routine group） and 146 patients were treated by plavix （75mg, qd） on the basis of routine and aspirin treatments （combined group） from June, 2014 to June, 2015, were analyzed retrospectively. The platelet aggregation rate was determined and the neurological defect was determined in all the patients by National Institute of Health stroke scale （NIHSS） score before and 2 weeks after the treatment. Results The platelet aggregation rates and NIHSS scores in both the combined and routine groups were significantly lower after the treatment than those before the treatment （P〈0.05）. The platelet aggregation rates and NIHSS scores were significantly lower in the combined group than those in the routine group 2 weeks after the treatment （P〈0.05）. Conclusion Aspirin and plavix can play a synergistic role in decrease of the platelet aggregation rate in the patients with ischemic stroke. The curative effect on the patients with ischemic stroke can be enhanced by aspirin combined with plavix.

关 键 词：缺血性脑卒中 阿司匹林 氯吡格雷 血小板聚集率 

分 类 号：R743[医药卫生—神经病学与精神病学]