脑卒中后抑郁与颈动脉粥样硬化的相关性  

Correlation of post-stroke depression and carotid artery atherosclerosis

作　　者：苑杰 王慧娟 徐士军[3] 张江 付华斌 刘昊 王海涛 王静[7] 

机构地区：[1]华北理工大学研究生学院,河北唐山063000 [2]华北理工大学 [3]唐山市人民医院神经内科 [4]华北理工大学附属医院神经内科 [5]华北理工大学附属解放军256医院 [6]华北理工大学基础学院 [7]唐山职业技术学院

出　　处：《中国老年学杂志》2017年第14期3438-3440,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(81201048);河北省医学科学研究重点课题计划(20150050;20160218);国家卫生计生委重点实验室(20150006);河北省中医药类科研计划课题(2016079)

摘　　要：目的探讨脑卒中后抑郁(PSD)与颈动脉粥样硬化的关系。方法 304例缺血性脑梗死患者,根据汉密尔顿抑郁量表(HAMD)评分结果,总分<8分者为非PSD组,≥8分者为PSD组,比较两组颈动脉内-中膜厚度(CIMT)和颈动脉粥样硬化斑块情况,分析PSD发生的危险因素。结果 PSD组CIMT增厚检出率(97.0%)较非PSD组(74.4%)高(P<0.01),PSD组CIMT厚度[(1.78±0.68)mm]大于非PSD组[(1.27±0.36)mm](P<0.01);PSD组斑块检出率(89.1%)较非PSD组(73.9%)高(P<0.01),PSD组斑块面积[(26.22±0.28)mm2]大于非PSD组[(13.25±0.16)mm2](P<0.01)。两组患者年龄、脑卒中次数和病灶数量比较差异有统计学意义(P<0.05)。Logistic回归分析结果显示,CIMT(P=0.000,OR=7.143,95%CI:3.559~14.335)和颈动脉粥样硬化斑块(P=0.020,OR=5.033,95%CI:1.288~19.665)是PSD的危险因素。结论 CIMT和颈动脉粥样硬化斑块是PSD发生的危险因素。Objective To investigate the relationship between post-stroke depression （PSD） and carotid artery atherosclerosis.Methods A total of 304 cerebral ischemic stroke patients hospitalized in department of neurology in North China University of Science and Technology from November 2015 to May 2016 were selected.According to the score of Hamilton depression （HAMD）, those who got the aggregate score 〈8 points were divided into the non-PSD group, while the others were divided into the PSD group.The carotid intima-media thickness （CIMT） and carotid atherosclerotic plaques were compared, and the risk factors for PSD were analyzed.Results The detection rate of thickening of CIMT in the PSD group （97.0%）was higher than that of the non-PSD group （74.4%,P〈0.01）;the CIMT thickness of the PSD group〔（1.78±0.68）mm〕 was greater than that of the non-PSD group 〔（1.27±0.36）mm,P〈 0.01〕;the detection rate of plaque in the PSD group （89.1%） was higher than that of the non-PSD group （73.9%,P〈0.01）;the plaque area of PSD group〔（26.22±0.28）mm^2〕 was greater than that of the non-PSD group 〔（13.25±0.16）mm^2,P〈0.01）〕.The CIMT（P=0.000,OR=7.143,95%CI：3.559~14.335）and carotid atherosclerosis plaque （P=0.020,OR=5.033,95%CI：1.288~19.665） were risk factors for the PSD according to Logistic regression analysis.Conclusions The CIMT and carotid atherosclerotic plaques are important risk factors of PSD.The clinical screening can refer to those indexes.

关 键 词：脑卒中后抑郁 颈动脉粥样硬化 颈动脉内-中膜厚度 斑块 

分 类 号：R749.1[医药卫生—神经病学与精神病学]