依达拉奉治疗急性脑出血的临床效果及安全性  

Clinical effect and safety of edaravone on acute cerebral hemorrhage

作　　者：成巧梅 

机构地区：[1]陕西省富县中医医院药剂科,陕西渭南727500

出　　处：《临床医学研究与实践》2017年第20期37-38,共2页Clinical Research and Practice

摘　　要：目的观察依达拉奉治疗急性脑出血的临床效果及安全性。方法将78例我院收治的急性脑出血患者采用随机数表法分为对照组和观察组,每组39例。对照组采用常规对症支持治疗,观察组在常规治疗的基础上给予依达拉奉治疗。比较两组治疗效果,治疗前、后的NO、SOD、LPO、GP水平及治疗过程中不良反应发生情况。结果两组治疗14 d后,观察组患者的临床总有效率达94.87%,显著高于对照组的76.92%(P<0.05)。两组治疗前的NO、SOD、LPO、GP水平比较,无显著差异(P>0.05);治疗14 d后,两组的NO、LPO水平显著低于治疗前,SOD、GP水平明显高于治疗前,且观察组的上述指标均优于对照组(P<0.05)。两组不良反应发生率比较,无显著差异(P>0.05)。结论依达拉奉治疗急性脑出血临床效果显著,可有效清除氧自由基,不良反应少,值得临床推广应用。Objective To observe the clinical effect and safety of edaravone on acute cerebral hemorrhage. Methods Seventy eight cases of patients with acute cerebral hemorrhage were divided into control group and observation group according to the random table method, with 39 cases in each group. The control group used conventional support treatment,while the observation group added edaravone on the basis of the conventional support treatment, the treatment effects, NO,SOD, LPO, GP levels before and after treatment and adverse reactions were compared in the two groups. Results After 12 d treatment, the total effective rate of the observation group was 94.87%, which was significantly higher than 76.92% of the control group（P〈0.05）. Before treatment, there were no significant differences in the NO, SOD, LPO, GP levels between the two groups（P〈0.05）. After 12 d treatment, the NO, LPO levels in the two groups were lower than those before treatment,while SOD, GP levels were higher than those before treatment, those indexes in the observation group were better than the control group（P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P〈0.05）. Conclusion Edaravone has remarkable effect on acute cerebral hemorrhage, which can effectively clear away oxygen free radicals, and has less adverse reactions, it is worthy of clinical application.

关 键 词：依达拉奉 急性脑出血 NO SOD LPO GP 

分 类 号：R743.3[医药卫生—神经病学与精神病学]