急性期应用糖皮质激素对急性面神经麻痹预后的影响  

Influence of glucocorticoid on prognosis of acute facial paralysis in acute stage

作　　者：王娟 张桂芳 郭岩 

机构地区：[1]陕西省友谊医院内一科,陕西西安710068

出　　处：《临床医学研究与实践》2017年第21期17-18,共2页Clinical Research and Practice

摘　　要：目的研究急性期应用糖皮质激素对急性面神经麻痹预后的影响。方法纳入90例急性面神经麻痹患者,按随机抽签法分为三组,各30例。观察A组给予泼尼松30 mg/d干预,观察B组给予泼尼松20 mg/d干预,对照组行非激素治疗方案。比较三组患者的治疗效果。结果观察A、B组治疗总有效率、治疗后面部肌肉功能评分及患侧与健侧M波波幅比均显著优于对照组(P<0.05)。观察A、B两组间临床疗效、面部肌肉功能评分及患侧与健侧M波波幅比比较无显著性差异(P>0.05)。三组不良反应发生率比较无显著性差异(P>0.05)。结论面神经麻痹急性期患者短期小剂量应用糖皮质激素疗效显著,能有效改善面部神经功能,且安全性较高,预后满意。Objective To study the influence of glucocorticoid on prognosis of acute facial paralysis in acute stage. Methods Ninety cases of patients with acute facial paralysis were randomly divided into three groups, with 30 cases in each group. Group A was treated with prednisone 30 mg/d, group B was treated with prednisone 20 mg/d, the control group was treated with non hormonal therapy. The clinical effects were compared among the three groups. Results The total effective rate, posterior muscle function score after treatment and M wave amplitude ratio between affected and healthy side of group A and group B were significantly better than those of the control group （P〈0.05）. There was no significant difference in the total effective rate, posterior muscle function score after treatment and M wave amplitude ratio between group A and group B （P〉0.05）. There was no significant difference in adverse reaction among the three groups （P〉0.05）. Conclusion The patients with facial paralysis in acute stage can apply short term of glucocorticoid, which has significant effect, and can effectively improve facial nerve function, with high safety and satisfactory prognosis.

关 键 词：面神经麻痹 急性期 糖皮质激素 预后 

分 类 号：R745.12[医药卫生—神经病学与精神病学]