进展期胃癌术前介入化疗的临床可行性研究  

Clinic feasibility research of preoperative intraarterial chemotherapy in advanced gastric carcinoma

作　　者：李书沛 蒋明[1] 来凤勇[1] 陆晓[1] 高小盼 尹治清[1] 周福有[1] 

机构地区：[1]河南科技大学临床学院、安阳市肿瘤医院,河南安阳455000

出　　处：《临床研究》2017年第6期5-6,共2页Clinical Research

摘　　要：目的 研究进展期胃癌术前介入化疗的临床可行性.方法 选择2013年3月至2014年6月我院收治的进展期胃癌患者共40例作为研究对象,施行术前介入化疗.其中,肿块型进展期胃癌患者有15例,浸润溃疡型进展期胃癌患者有25例.结合进展期胃癌患者的实际病情以及病灶具体部位进行动脉选择性插管,化疗药物依据进展期胃癌患者的体表面积使用.术前介入化疗结束后7~14 d再给予手术治疗,并将标本做病理检查.结果 有16例患者出现恶心呕吐情况,其中有1例黑便,经过对症治疗后症状缓解;所有患者均顺利完成手术,手术结束后均无感染等严重术后并发症;肿块型化疗反应率为86.67%、浸润溃疡型化疗反应率为68.00%;手术后持续跟踪随访2年期间复发情况：术后6个月0.00%（0/40）,术后12个月2.50%（1/40）,术后18个月12.50%（5/40）,术后24个月22.50%（9/40）.术后第1年生存率为95.00%（38/40）,第2年生存率为80.00%（32/40）.结论 给予进展期胃癌患者术前介入化疗,手术切除成功率高,而且患者手术后复发率低,不良反应发生情况低,值得临床应用.Objective To investigate the clinic feasibility of preoperative intraarterial chemotherapy in advanced gastric carcinoma. Methods From March 2013 to June 2016, a total of 40 cases of patients with advanced gastric carcinoma in our hospital were selected and given preoperative intraarterial chemotherapy. There were 15 cases of patients with mass type ad- vanced gastric carcinoma and 25 cases of patients with ulcer infiltration type advanced gastric carcinoma. All patients were given selective artery intubation according to actual condition and chemotherapeutics according to body surface area of pa- tients. After 7~14 days preoperative intraarterial chemotherapy, patients were given operative treatment, and specimen were given pathological examination. Results There were 16 cases of patients with nausea and vomiting, including 1 case of me- lena, and the symptoms relieved after expectant treatment; all surgery were successfully completed, no severe postoperative complications occurred; the mass type chemotherapy and ulcer infiltration type chemotherapy reaction rate were 86.67% and 68.00%; recurrence condition after 2 years follow up： after 6、12、18 and 24 months, the recurrence were 0.00% （0/40）, 2.50% （1/40）, 12.50% （5/40） and 22.50% （9/40）. Survival rate after 1 and 2 years were 95.00% （38/40） and 80.00% （32/40）. Conclusion The treatment of preoperative intraarterial chemotherapy can improve the success rate of surgery, has lower postoperative recurrent rate and adverse reactions, which is worthy of clinical application.

关 键 词：进展期胃癌 介入治疗 组织病理学 复发率 

分 类 号：R735.2[医药卫生—肿瘤]