氟化钠-壳聚糖凝胶对乳牙釉质早期龋再矿化实验观察  

An in vitro study of re-mineralization of enamel with early caries in primary teeth treated by NaF-chitosan gel

作　　者：周红艳[1] 臧睿觉 王珏[1] 刘茜[1] 张晓旻[1] 曹灵[1] 梅予锋[1] 

机构地区：[1]南京医科大学口腔疾病研究江苏省重点实验室,南京医科大学口腔医学院儿童口腔科预防口腔科,210029 [2]南京市口腔医院儿童口腔科

出　　处：《实用口腔医学杂志》2017年第4期550-553,共4页Journal of Practical Stomatology

基　　金：江苏省卫生计生委预防医学科研课题(编号:Y2015051);江苏高校品牌专业建设工程资助(编号:PPZY2015B163)

摘　　要：目的:探讨氟化钠壳聚糖凝胶促进乳牙釉质早期龋模型再矿化的可行性。方法:乳前牙试件使用乳酸羧甲基纤维素凝胶预处理,制备早期龋模型;早期龋的乳前牙试件随机分成4组(n=6),3组分别进行氟化钠壳聚糖凝胶、壳聚糖空白凝胶、多乐氟处理,1组作为空白对照,处理完成后进行p H循环,SEM、EDS检测循环完成后的试件表面。结果:SEM观察,氟化钠壳聚糖凝胶能更好的保护釉质表层结构不受破坏,而多乐氟和空白对照组,则表现出釉质表层的崩解。同时氟化钠壳聚糖凝胶有更多的矿化物结晶在釉质表面形成。EDS检测钙离子的沉积比例,氟化钠壳聚糖凝胶组明显多于其余各组(P<0.05)。结论:氟化钠壳聚糖凝胶可以提高乳前牙早期龋的再矿化水平。Objective： To estimate the remineralization of enamel of primary teeth with early caries protreated by NaF-chitosan gel. Methods： Early stage caries was created on anterior primary teeth. The samples were divided into 4 groups randomly（ n = 6）, and treated by NaF-ehitosan gel, chitosan gel, duraphat and non- treatment（ the control） respectively. Then all samples were underwent a 7 days pH cycle. Then samples were tested with SEM and EDS. Data were analyzed with SPSS 19. Results： The SEM data showed that chitosan gel protected the enamel surface from being ruined by erosion. NaF-chitosan gel group showed more mineral crystal formation on the enamel surface. The NaF-chitosan gel group showed more Ca remineralized on the enamel surface. Conclusion： NaF-chitosan gel can increase the remineraliztion of on the anterior primary teeth with early stage caries.

关 键 词：壳聚糖水凝胶 氟化钠 乳牙 早期龋 再矿化 

分 类 号：R781.1[医药卫生—口腔医学]