IL-6 C-572G多态性位点与自发性早产遗传易感性的关系  

Association between IL-6 C-572G and susceptibility to spontaneous preterm birth

作　　者：杨晓[1,2,3] 彭薇[1,2,3] 朱丽娜[1,2,3] 张小爱[4] 王艳[1,2,3] 

机构地区：[1]中国人民解放军陆军总医院附属八一儿童医院发育生物学实验室,北京100700 [2]出生缺陷防控关键技术国家工程实验室,北京100700 [3]儿童器官功能衰竭北京市重点实验室,北京100700 [4]军事医学科学院微生物和流行病学研究所病原微生物生物安全重点实验室,北京100071

出　　处：《中国当代儿科杂志》2017年第7期806-811,共6页Chinese Journal of Contemporary Pediatrics

基　　金：国家自然科学基金(81300527)

摘　　要：目的探讨IL-6基因C-572G多态性位点与自发性早产(SPTB)遗传易感性的关联性。方法研究对象来自北京及其周边地区。病例组包括569例SPTB新生儿,其中超早产儿(胎龄<28周)56例、极早产儿(胎龄28~31^(+6)周)166例和中晚期早产儿(胎龄32~36^(+6)周)347例。对照组包括673例足月新生儿。采用最新的Sequenom Mass ARRAY~?SNP检测技术对IL-6基因C-572G位点进行单核苷酸多态性分型。结果与携带IL-6基因C-572G位点的CC基因型的个体相比,携带至少1个G等位基因型(CG+GG基因型)的个体发生中晚期SPTB的风险显著升高(OR=1.35,95%CI:1.01~1.80,P=0.04)。结论在该中国人群中,IL-6基因C-572G多态性位点与中晚期SPTB患病风险的增加存在显著的遗传学关联。Objective To investigate the association between the genetic polymorphism of IL-6 C-572G and susceptibility to spontaneous preterm birth （SPTB）. Methods The subjects were from Beijing and the surrounding areas of Beijing. This case-control study enrolled 569 SPTB infants, including 56 extremely preterm （〈28 weeks of gestation）, 166 very preterm （28-31＋6 weeks of gestation） and 347 moderate to late preterm infants （32 to 36＋6 weeks of gestation）. A total of 673 term infants were enrolled as the control group. The latest Sequenom MassARRAYSNP detection technique was used for the typing of single nucleotide polymorphism of IL-6 C-572G. Results Compared with the CC genotypes, the IL-6 C-572G G-positive genotype （CG＋GG genotype） was significantly associated with an increased susceptibility to moderate to late SPTB （OR=1.35, 95%CI： 1.01-1.80, P=0.04）. Conclusions Among the Chinese population, IL-6 C-572G polymorphism is associated with susceptibility to moderate to late SPTB. [Chin J Contemp Pediatr, 2017, 19（7）： 806-811]

关 键 词：白细胞介素6 自发性早产 单核苷酸多态性 易感性 早产儿 

分 类 号：R722.6[医药卫生—儿科]