罗哌卡因复合帕瑞昔布钠应用于颅脑肿瘤切除术患者麻醉中的效果  

Application of Ropivacaine Combined with Parecoxib Sodium in Anesthesia of Brain Tumor Resection

作　　者：周明星[1] 李进[1] 袁军[1] 

机构地区：[1]武汉市第一医院,430071

出　　处：《实用癌症杂志》2017年第8期1240-1243,共4页The Practical Journal of Cancer

摘　　要：目的探讨罗哌卡因复合帕瑞昔布纳应用于颅脑肿瘤患者麻醉的效果及对血糖、肾上腺素、皮质醇等的影响。方法选取98例行颅脑肿瘤切除术患者作为研究对象,按照随机数字表法分为观察组49例和对照组49例。2组患者进入手术室后均常规监测血压、血氧饱和度、心电图、平均动脉压及鼻咽温度,给予麻醉诱导、麻醉维持。对照组采用生理盐水20 m L于切皮前10 min行浸润麻醉,手术完成前30 min静脉注射生理盐水2 m L;观察组采用0.5%罗哌卡因20 m L于切皮前10 min浸润麻醉,手术完成前30 mn静脉射帕瑞昔布纳40 mg+生理盐水2 m L。比较2组患者麻醉效果、血糖、肾上腺素、去甲肾上腺素、皮质醇、心率、平均动脉压及不良反应发生情况。结果麻醉后观察组麻醉效果持续时间显著长于对照组,而麻醉恢复时间、气管拔管时间均明显短于对照组(P<0.05);2组患者术毕、拔管后血糖、肾上腺素、去甲肾上腺素、皮质醇水平显著高于诱导前(P<0.05),但观察组上升幅度明显低于对照组(P<0.05);2组患者心率、平均动脉压及各不良反应比较,差异无统计学意义(P>0.05)。结论罗哌卡因复合帕瑞昔布纳应用于颅脑肿瘤切除术患者麻醉效果确切,有效降低术中应激反应,降低对脑组织损伤,安全可靠,值得临床推广。Objective To study the application of ropivacaine combined with parecoxib sodium in anesthesia of brain tumor resection, and its effect on blood glucose, adrenaline and cortisol. Methods 98 patients with brain tumor l^section were se- lected as the subjects, and were divided into the observation group（49 cases） and the control group（49 cases）. ＇File 2 groups were routinely monitoring blood pressure, oxygen saturation, electrocardiogram, mean arterial pressure and nasopharyngeal temperature, giving anesthesia, maintenance of anesthesia after entering the operating room. The control group were treated with 20 mL saline in 10 min before incision for anesthesia, and intravenous injection of 2 mL saline in 30 min before surgery completed. While the ob- servation group were treated with 20 mL 0.5% ropivacaine in 10 min before incision for anesthesia,and intravenous injection of 2 mL saline in 30 rain before surgery completed. Compare the anesthesia, blood glucose, epinephrine, norepinephrine, cortisol, heart rate,mean arterial pressure and adverse events of the 2 groups. Results After anesthesia,the anesthesia duration of the observa- tion group were significantly longer than those of the control group（P 〈0.05） ,and the anesthesia recovery time,extubation time of the observation group were significantly shorter than those of the control group （ P 〈 O. 05 ） ; After surgery and extubation, in terms of glucose, epinephrine, norepinephrine, cortisol, the patients of the 2 groups were all significantly increased than before in- duction（ P 〈 O. 05 ） , and the patients of the control group got a higher upgrade （P 〈 0.05 ） ;In terms of heart rate, mean arterial pressure and other adverse reactions, there were no significantly difference between the 2 groups （ P 〉 0.05 ）. Conclusion Ropiv- acaine combined with pareeoxib sodium in anesthesia of brain tumor resection is effective, it can effectively reduce intraoperative stress and brain tissue damage, and it is safety and reliable, it is w

关 键 词：罗哌卡因 颅脑肿瘤切除术 血糖 肾上腺素 皮质醇 

分 类 号：R739.41[医药卫生—肿瘤]