多层螺旋CT灌注成像评价肺癌的血供特征  

The Evaluation of Hemodynamic Features of Lung Malignancies with Multislice Spiral CT Perfusion Imaging

作　　者：谭泽兵[1] 张子曙[2] 王云华[2] 李丽艳[3] 周顺科[2] 

机构地区：[1]中国人民解放军国防科技大学医院放射科,湖南长沙410073 [2]中南大学湘雅二医院放射科,湖南长沙410011 [3]吉林市第二中心医院放射科,吉林132021

出　　处：《湖南师范大学学报（医学版）》2009年第4期42-46,共5页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:运用多层螺旋CT灌注成像技术,研究不同细胞学类型肺癌血供特征。方法:经组织病理学证实的45例肺癌患者,先行常规肺部CT平扫,确定病变部位,而后以6ml/s的速度注射碘浓度为300mg/mL的非离子增强剂50ml,对病变行同层动态扫描。在西门子工作站用Body Perfusion软件中的Lung Cancer子软件处理数据,计算肿瘤的灌注参数。应用方差分析比较不同类型肺癌的灌注值。结果:腺癌灌注起始时间要迟于鳞癌和小细胞未分化癌。鳞癌达峰时间要早于腺癌和小细胞未分化癌。肺癌的其它灌注值在细胞学类型之间没有统计学意义上的差异。结论:肺癌灌注起始时间和灌注达峰时间在肺癌不同病理类型中有差异,它们对判断肺癌的细胞学分型的价值还可能需要更进一步的研究和探讨。其它灌注值在肺癌的细胞学分型没有统计学差别,可能对于肺癌分型的鉴别作用不大。Objective To investigate th e hemodynamic features of different cytopathological types of lung malignancies on multislice spiral CT perfusion imaging.Methods Forty-five patients with histologically proven lung cancers were involved in this study.A conventional thoracic CT was obtained as a routine to locate the lung lesions.Fifty milliliters of nonionic contrast(300 mgI/ml) were injected at 6 ml/s,then,followed by dynamic CT scans at the same location.Data postprocessing was performed on Siemens workstation using lung cancer analyzing software in the package of Body Perfusion.The perfusion measurements were calculated for each dynamic scan.The perfusion values of different types of lung malignancies were then compared using analysis of variance.Results The time to start perfusion of lung adenocarcinomas was later than the time of squamous cell carcinomas and small cell undifferentiated carcinomas.The time to peak perfusion of squamous cell carcinomas was earlier than lung adenocarcinomas and small cell undifferentiated carcinomas.No significant differences were noted on other perfusion values among different cytopathological types of lung malignancies.Conclusion The Significant differences were noted on the values of time to start and time to peak perfusion among different cytopathological types of lung malignancies,but further investigation is necessary for their significance of prediction the cytopathology of lung malignancies.No significant differences were noted on other perfusion values among different types of lung malignancies.They may be of little help on differentiation of different cytopathological types of lung malignancies.

关 键 词：灌注成像 CT 肺癌 病理分型 

分 类 号：R734.2[医药卫生—肿瘤]