卡马西平应用于癫痫治疗中的临床观察  

Clinical observation of carbamazepine in epilepsy treatment

作　　者：吕云惠 赵正戈 邓家军 

机构地区：[1]辽宁省庄河市中医医院(内二科)神经内科,辽宁庄河116400

出　　处：《当代医学》2017年第22期55-58,共4页Contemporary Medicine

摘　　要：目的探讨卡马西平治疗癫痫的临床效果。方法选取因癫痫来神经科就诊的126例患者,随机分为对照组和观察组,各63例。均采取个体化单一给药原则,对照组给予托吡酯,观察组给予卡马西平,随时调整用药剂量,观察两组治疗后1年内脑电图癫痫波分布情况,评估临床疗效,同时监测不良反应事件,计算不良反应发生率。结果治疗后观察组有15例患者无癫痫波发生,癫痫波分布情况及治疗总有效率明显高于对照组(95.2%vs 77.8%),未出现重度不良反应或因此停药者,不良反应发生率明显低于对照组(4.8%vs 12.7%),组间比较差异具有统计学意义(P<0.05)。结论卡马西平治疗癫痫疗效确切,安全性高,在做好安全性监测的前提下可推广使用。Objective To investigate the clinical effect of carbamazepine in the treatment of epilepsy. Methods 126 patients with neuropathy who were treated with epilepsy were randomly divided into control group and observation group. The rats in the control group were treated with ear- bamazepine and the dosage was adjusted at any time. The distribution of EEG epileptic wave in the two groups was observed at 1 year after treat- ment. The clinical efficacy was evaluated and the adverse events were monitored., Calculate the incidence of adverse reactions. Results The inci- dence of epileptic seizures and the total effective rate of epilepsy were significantly higher in the 15 patients than in the control group （95.2% vs 77.8%）. There were no severe adverse reactions or discontinued patients. The incidence was significantly lower than the control group （4.8% vs 12.7%）, the difference between the groups was statistically significant （P〈0.05）. Conclusion Carbamazepine is effective in the treatment of epilep- sy and has high safety and can be used in the field of safety monitoring.

关 键 词：卡马西平 癫痫 癫痫波 临床疗效 安全性 

分 类 号：R742.1[医药卫生—神经病学与精神病学]