三七皂苷元的乙酰化结构修饰及活性研究  

Acetylation Structure Modification of Sapogenins of Panax Notoginseng Saponins and Activity Researches of the Products

作　　者：郭巍怡 段文越[1] 邹澄[1] 赵庆[2] 杨为民[1] 陈晨[1] 李瑞[1] 黄丽[1] 

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500 [2]云南中医学院中药学院,云南昆明650500

出　　处：《云南中医学院学报》2017年第3期78-82,共5页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81160388)

摘　　要：目的研究三七总皂苷酸水解后得到的酰化产物的化学成分及其药理活性,期望从中发现有活性的物质。方法酸性条件下水解三七总皂苷得到酰化产物,利用硅胶柱色谱和重结晶方法分离纯化,通过核磁共振技术对酰化产物的结构进行鉴定,并研究上述产物的抗肿瘤活性和血管舒张活性。结果酸水解后,分离纯化得到7个酰化产物,其中3个化合物具有一定的抗肿瘤活性,1个化合物具有一定的舒张大鼠脑血管活性。结论三七皂苷元的酰化衍生物具有一定的药理活性,值得进一步研究。Objective To study the chemical constituents and pharmacological activities of acylation products of acid hydrolysis of Panax notoginseng saponins and to find active substances. Methods Under acidic condition, Panax notoginseng saponins were hydrolyzed to obtain the acylation products. The compounds were isolated and purified by silica gel column chromatography and recrystal ization , and the structures of the acylated products were identified by NMR, and study the antitumor activity and vasodilation activity of the products. Results After acid hydrolysis , seven acylated products were obtained , three compounds have some antitumor activity , one compound has some vasodilation of rat brain. Conclusions Acylated derivatives of sapogenins of Panax notoginseng saponins have certain pharmacological activity and were worthy of further study.

关 键 词：三七总皂苷 酸水解 酰化产物 抗肿瘤活性 血管舒张活性 

分 类 号：R284.1[医药卫生—中药学]